Last year we found that regulatory T cells infiltrated into the liver of female Balb/cJ mice following halothane treatment and inhibited both humoral and cellular immune reactions against trifluoroacetylated proteins formed in vivo following halothane treatment. This year we report that newly discovered myeloid-derived suppressor cells also infiltrated into the liver of female Balb/cJ mice following halothane treatment. These cells have be shown recently to inhibit effector T cell activity in tumors, infections, and in autoimmune diseases. Conclusion: These findings suggest that both regulatory T cells and myeloid-derived suppressor cells might have a role in preventing drug-protein adducts from causing liver injury mediated by the adaptive immune system and that deficiencies in the activities of these regulatory cells might be susceptibility factors in DILD.
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|Proctor, William R; Chakraborty, Mala; Chea, Lynette S et al. (2013) Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice. Hepatology 57:2026-36|
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