Abstract

HSP90a plays an important role in regulating enzymes important for metabolic functions such as eNOS and LKB1. Therefore, it is possible that HSP90a plays a broader role in the regulation of energy metabolism in whole animals. We analyzed how HSP90 changes with aging in skeletal muscle and fat in animals. We find that expression and activity of HSP90a decreases with aging in primates and in rodents. HSP90a is also important for the activity of a number of enzymes that are important for energy metabolism and metabolic rate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHL006119-02
Application #
8558058
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2012
Total Cost
$1,108,695
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Chung, Jay H (2018) The role of DNA-PK in aging and energy metabolism. FEBS J 285:1959-1972
Park, Sung-Jun; Gavrilova, Oksana; Brown, Alexandra L et al. (2017) DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab 25:1135-1146.e7