We developed a new diffusion MRI protocol called Principle-Component Analysis Temporal Maximal Intensity Projection to overcome the problems associated with physiological motion, and demonstrated its superior image qualities in human normal volunteers and in heart disease patients. Currently it is being further evaluated at our collaborator clinical site at the Radiology Department of the University of Lyon, France. It has potential applications in all types of diffusion MRI diagnostic protocols ranging from the brain to the prostate.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Heart, Lung, and Blood Institute
Zip Code
Pai, Vinay M; Kozlowski, Megan; Donahue, Danielle et al. (2012) Coronary artery wall imaging in mice using osmium tetroxide and micro-computed tomography (micro-CT). J Anat 220:514-24
Rapacchi, Stanislas; Wen, Han; Viallon, Magalie et al. (2011) Low b-value diffusion-weighted cardiac magnetic resonance imaging: initial results in humans using an optimal time-window imaging approach. Invest Radiol 46:751-8
Pai, V M; Rapacchi, S; Kellman, P et al. (2011) PCATMIP: enhancing signal intensity in diffusion-weighted magnetic resonance imaging. Magn Reson Med 65:1611-9