We have recently (February 2017) moved laboratories from London to the NIH. While working here, we have obtained data defining the pathways by which intracellular C5 is activated in human T cells and monocytes and have shown that this intracellular C5 activation is critical to IL-1b production by T cells/monocytes. We are currently assessing the in vivo biological significance of this observation using appropriate CVD mouse models. We are also testing the effects of cell-permeable C5 inhibitors in vitro with an eye on the development of preclinical models.
|Kolev, Martin; Kemper, Claudia (2017) Keeping It All Going-Complement Meets Metabolism. Front Immunol 8:1|
|Arbore, Giuseppina; Kemper, Claudia; Kolev, Martin (2017) Intracellular complement - the complosome - in immune cell regulation. Mol Immunol :|
|Freeley, Simon; Kemper, Claudia; Le Friec, Gaëlle (2016) The ""ins and outs"" of complement-driven immune responses. Immunol Rev 274:16-32|
|Arbore, Giuseppina; Kemper, Claudia (2016) A novel ""complement-metabolism-inflammasome axis"" as a key regulator of immune cell effector function. Eur J Immunol 46:1563-73|