Our work this past year has covered 3 distinct areas structural bioinformatics, systems pharmacology and scholarly communication. Progress in each area is discussed separately. In total our work has produced 16 publications since March 2014, the date I started at NIH, and a little more that the reporting period. Several additional papers are currently under review. My H factor is currently 54 and I have accrued 32,562 citations according to Google Scholar. I have 206 publications in PubMed. Structural Bioinformatics Our work here has focused on improved algorithms for detecting symmetry in proteins (with (now Dr.) Spencer Bliven) and the functional and evolutionary implications on those findings (with Drs. Philippe Youkharibache and Stella Veretnik). The former quantified the concept of a protodomain a substructure smaller than a domain that shows approximate symmetry and is assumed to have arisen from a gene duplication. The later has led to a study of small beta barrels which while small exhibit a protodomain structure and enormous versatility of function either alone or as multimers. In a multimeric state they belong to a variety of organizations that when misfolding occurs can lead to aggregation and association leading to a variety of disease states. Systems Pharmacology Work here focused on exploring opportunities to repurpose existing drugs for the treatment of Ebola (with Drs. Lei Xie and Zheng Zhao) and two reviews for Frontiers in Pharmacology and PLOS Computational Biology (>12,000 views), the first focused on cancer treatment as a complex disease and the latter on the role of systems pharmacology in personalized medicine. Scholarly Communication A variety of activities have been undertaken by Dr. Daniel Mietchen including help in organizing an open science prize, a workshop on the disparity between funders and publishers data sharing policies, data citation standards and software, transparency in research funding and the development of data sharing plans.
| Brunk, Elizabeth; Mih, Nathan; Monk, Jonathan et al. (2016) Systems biology of the structural proteome. BMC Syst Biol 10:26 |
| Zhao, Zheng; Martin, Che; Fan, Raymond et al. (2016) Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology. BMC Bioinformatics 17:90 |
| Berg, Jeremy M; Bhalla, Needhi; Bourne, Philip E et al. (2016) SCIENTIFIC COMMUNITY. Preprints for the life sciences. Science 352:899-901 |
| McKiernan, Erin C; Bourne, Philip E; Brown, C Titus et al. (2016) How open science helps researchers succeed. Elife 5: |
| Wilkinson, Mark D; Dumontier, Michel; Aalbersberg, I Jsbrand Jan et al. (2016) The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 3:160018 |
| Zhao, Zheng; Xie, Li; Xie, Lei et al. (2016) Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach. J Med Chem 59:4326-41 |
| Prins, Pjotr; de Ligt, Joep; Tarasov, Artem et al. (2015) Toward effective software solutions for big biology. Nat Biotechnol 33:686-7 |
| Berman, Francine D; Bourne, Philip E (2015) Let's Make Gender Diversity in Data Science a Priority Right from the Start. PLoS Biol 13:e1002206 |
| Quinn, Gregory B; Bi, Chunxiao; Christie, Cole H et al. (2015) RCSB PDB Mobile: iOS and Android mobile apps to provide data access and visualization to the RCSB Protein Data Bank. Bioinformatics 31:126-7 |
| Erren, Thomas C; Slanger, Tracy E; Groß, J Valérie et al. (2015) Ten simple rules for lifelong learning, according to Hamming. PLoS Comput Biol 11:e1004020 |
Showing the most recent 10 out of 30 publications
