Roles of Oxytocin and Vasopressin in Brain

Young, Walter Scott

Abstract

--This fiscal year, we continued our studies of our gene knockouts (KO) of the mouse oxytocin (Oxt) and vasopressin (Avp) 1b receptors (Oxtr and Avpr1b, respectively) to investigate their specific roles in mediating behavior. Avp and Oxt are neurohormones

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAMH002498-26
• Application #: 9152075
• Support Year: 26
• Fiscal Year: 2015

Institution

• Name: U.S. National Institute of Mental Health

Publications

Young, W Scott; Song, June; Mezey, Éva (2018) Hybridization Histochemistry of Neural Transcripts. Curr Protoc Neurosci 82:1.3.1-1.3.27

Mayer, Balázs; Németh, Krisztián; Krepuska, Miklós et al. (2017) Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia. Sci Transl Med 9:

Oettl, Lars-Lennart; Ravi, Namasivayam; Schneider, Miriam et al. (2016) Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing. Neuron 90:609-21

Young, W Scott; Song, June; Mezey, Éva (2016) Hybridization Histochemistry of Neural Transcripts. Curr Protoc Neurosci 75:1.3.1-1.3.27

Patial, Sonika; Stumpo, Deborah J; Young 3rd, W Scott et al. (2016) Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome. Mol Cell Biol 36:1395-411

Smith, A S; Williams Avram, S K; Cymerblit-Sabba, A et al. (2016) Targeted activation of the hippocampal CA2 area strongly enhances social memory. Mol Psychiatry 21:1137-44

Pagani, J H; Zhao, M; Cui, Z et al. (2015) Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Mol Psychiatry 20:490-9

Pagani, J H; Williams Avram, S K; Cui, Z et al. (2015) Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only. Genes Brain Behav 14:167-76

Choi, Ji-Woong; Kang, Sung-Min; Lee, Youngkyun et al. (2013) MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA. J Neurochem 126:331-7

Young, W Scott (2013) Shedding heat on oxytocin. Endocrinology 154:3961-2