During the past year we have investigated the prevalence and clinical correlates of attention deficit hyperactivity disorder (ADHD) under the definitions of DSM-IV and DSM-5 using NHANES/CDISC data. The results showed that extension of the age-of-onset criterion from 7 to 12 years lead to about a 30% increase in the prevalence of ADHD. The clinical significance of the early and later age of onset groups is comparable supporting the DSM-5 extension of the age of onset criterion in ADHD. Public Health Impact: These findings report the implications of extending the age of onset of ADHD symptoms from 7 to 12 years of age, as stipulated by the DSM-5, using parent reports from the nationally representative sample of adolescents. The study is essential to integrate data about the developmental nature of the disorder into diagnostic criteria that are valid and useful. Future Plans: Several ongoing projects using the NHANES and CDISC data include: 1) examining the association between threshold and subthreshold major depressive disorder and inflammatory and vascular biomarkers (Marques et al, 2014 ready for submission);and 2) evaluating the relationships between self-reported physical activity or objectively measured physical activity and mental disorders.

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U.S. National Institute of Mental Health
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Vande Voort, Jennifer L; He, Jian-Ping; Jameson, Nicole D et al. (2014) Impact of the DSM-5 attention-deficit/hyperactivity disorder age-of-onset criterion in the US adolescent population. J Am Acad Child Adolesc Psychiatry 53:736-44
Zhang, Jihui; Lamers, Femke; Hickie, Ian B et al. (2013) Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates. Sleep 36:671-9
Richardson, Amanda; He, Jian-Ping; Curry, Laurel et al. (2012) Cigarette smoking and mood disorders in U.S. adolescents: sex-specific associations with symptoms, diagnoses, impairment and health services use. J Psychosom Res 72:269-75
Bandiera, Frank C; Richardson, Amanda Kalaydjian; Lee, David J et al. (2011) Secondhand smoke exposure and mental health among children and adolescents. Arch Pediatr Adolesc Med 165:332-8
Merikangas, Kathleen Ries; He, Jian-Ping; Brody, Debra et al. (2010) Prevalence and treatment of mental disorders among US children in the 2001-2004 NHANES. Pediatrics 125:75-81
Nelson, Karin B; Richardson, Amanda Kalaydjian; He, Jianping et al. (2010) Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med 164:358-62
Lateef, Tarannum M; Merikangas, Kathleen R; He, Jianping et al. (2009) Headache in a national sample of American children: prevalence and comorbidity. J Child Neurol 24:536-43
Shreeram, Srirangam; He, Jian-Ping; Kalaydjian, Amanda et al. (2009) Prevalence of enuresis and its association with attention-deficit/hyperactivity disorder among U.S. children: results from a nationally representative study. J Am Acad Child Adolesc Psychiatry 48:35-41