The collection of data from this cohort has now been completed and analyses of the data are now underway. The National Institute of Mental Health (NIMH) family study of affective spectrum disorder has included numerous comparable measures of psychiatric and cardiovascular phenotypes that can be analyzed to develop hypotheses for COLAUS and conversely. The first report of the findings from this study has recently been submitted for publication (Glaus J., et al 2011). Public Health Impact: Cardiovascular diseases, their well established risk factors and mental disorders have the greatest public health impact of all chronic non-infectious human diseases 1. Moreover, a recent World Health Organization (WHO) projection of future population health concluded that by 2030, unipolar depressive disorders and ischemic heart disease (IHD) will be among the three leading causes of disease burden worldwide. Given the major public health impact of both CVD/CVRF and mental disorders, the study of the mechanisms underlying their associations is of high clinical and scientific relevance. Future Plans: The next phase of this project involves analysis of the biomarker and clinical data in the Lausanne site. We then plan to integrate the family study data and common biomarkers from the NIMH Family Study with those of the COLAUS study to enhance analytic power and to cross-replicate the findings. The results will then be used to guide plans for future follow-up and extension of the study samples.

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Glaus, Jennifer; von Känel, Roland; Lasserre, Aurélie M et al. (2018) The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study. Depress Anxiety 35:360-371
Pocnet, Cornelia; Antonietti, Jean-Philippe; Strippoli, Marie-Pierre F et al. (2017) Personality, tobacco consumption, physical inactivity, obesity markers, and metabolic components as risk factors for cardiovascular disease in the general population. Psychol Health Med 22:932-939
Vandeleur, C L; Merikangas, K R; Strippoli, M-P F et al. (2014) Specificity of psychosis, mania and major depression in a contemporary family study. Mol Psychiatry 19:209-13
Glaus, Jennifer; Vandeleur, Caroline L; von Kanel, Roland et al. (2014) Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. J Psychiatr Res 58:36-45
Vandeleur, Caroline; Rothen, Stephane; Gholam-Rezaee, Mehdi et al. (2012) Mental disorders in offspring of parents with bipolar and major depressive disorders. Bipolar Disord 14:641-53
Glaus, J; Vandeleur, C; Gholam-Rezaee, M et al. (2012) Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. Acta Psychiatr Scand :