Abstract

The Tissue Array Research Program (TARP) focuses on the use of tissue microarrays (TMAs) in biomedical research. TMAs are collections of samples of formalin fixed, paraffin embedded tissue from tens to hundreds of patients on a single microscope slide for high throughput analysis of protein expression most often by immunohistochemistry. The TARP Lab focuses on production and application of TMAs for cancer research. The studies utilizing TMAs are typically identified at the identification of biomarkers for diagnosis, prognosis and prediction of response to therapy for cancer. The TARP Lab investigates quality issues pertaining to surgical pathology diagnostic samples in the form of formalin fixed paraffin embedded tisue, the most common source material for surgical pathology diagnosis in clinical care, as well as use in TMAs. Defining and refining quality parameters in pathology specimens is an essential element of development of robust clinical tissue based biomarkers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICBC010923-02
Application #
7969966
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$1,068,262
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Cho, Hanbyoul; Shin, Ha-Yeon; Kim, Sunghoon et al. (2014) The role of S100A14 in epithelial ovarian tumors. Oncotarget 5:3482-96
Kitano, Haruhisa; Chung, Joon-Yong; Ylaya, Kris et al. (2014) Profiling of phospho-AKT, phospho-mTOR, phospho-MAPK and EGFR in non-small cell lung cancer. J Histochem Cytochem 62:335-46
Cho, Hanbyoul; Noh, Kyung Hee; Chung, Joon-Yong et al. (2014) Synaptonemal complex protein 3 is a prognostic marker in cervical cancer. PLoS One 9:e98712
Palmieri, Diane; Duchnowska, Renata; Woditschka, Stephan et al. (2014) Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner. Clin Cancer Res 20:2727-39
Simpson, R Mark; Bastian, Boris C; Michael, Helen T et al. (2014) Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res 27:37-47
Cho, Hanbyoul; Kim, Sunghoon; Shin, Ha-Yeon et al. (2014) Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer. Genes Chromosomes Cancer 53:277-88
Chung, Joon-Yong; Braunschweig, Till; Hong, Seung-Mo et al. (2014) Assessment of vascular endothelial growth factor in formalin fixed, paraffin embedded colon cancer specimens by means of a well-based reverse phase protein array. Proteome Sci 12:27
Armani, Michael; Tangrea, Michael; Yang, Brian et al. (2014) Multiplex quantitative measurement of mRNAs from fixed tissue microarray sections. Appl Immunohistochem Mol Morphol 22:323-30
Dan, T; Hewitt, S M; Ohri, N et al. (2014) CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up. Breast Cancer Res Treat 143:11-8
Keay, Tyler; Conway, Catherine M; O'Flaherty, Neil et al. (2013) Reproducibility in the automated quantitative assessment of HER2/neu for breast cancer. J Pathol Inform 4:19

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