The core facilities support translational research in the imaging sciences. Radiology and Imaging Sciences has evolved over the years. Supporting imaging research with core facilities and training academic radiologists and imaging scientists in the Intramural Program is the main goal. The Laboratory for Diagnostic Radiology Research has evolved into a more broad program for core support of translational research related to Radiology and Imaging Sciences, maintaining infrastructure for core basic science radioactive and non-radioactive lab facilities in Radiology with biology, molecular biology bays, synthetic chemistry bays, in vivo and ex vivo microscopy, BSL 2 tissue culture rooms, cold rooms, confocal microscopy, in vivo microscopy, contrast agent development, stem cell trafficking, cell migration, nanoparticle analysis and characterization, integrin antagonist synthetic chemistry, multi-modality probes, atherosclerosis probes, molecular imaging of colonic polyps, multi-modality imaging, molecular interventions, and liposomal chemistry. The core facility also now operates a micro-positron emission tomography (PET) and micro-computerized tomography (CT) system for performing PET/CT evaluating structural and metabolic changes in rodent models. There is also a 7T MRI Microimager and 3T clinical MRI scanner available to the scientists. There is a variety of shared equipment and facilities in the department that supports Radiology and Imaging Sciences Investigators and collaborative Intramural Investigators and labs, as well as the training of junior clinical, translational and basic science investigators.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICCL040013-09
Application #
9339291
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
Zip Code
Jain, Sanjay K; Tobin, David M; Tucker, Elizabeth W et al. (2018) Tuberculous meningitis: a roadmap for advancing basic and translational research. Nat Immunol 19:521-525
Riggle, Brittany A; Sinharay, Sanhita; Schreiber-Stainthorp, William et al. (2018) MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A 115:E12024-E12033
Tu, Tsang-Wei; Ibrahim, Wael G; Jikaria, Neekita et al. (2018) On the detection of cerebral metabolic depression in experimental traumatic brain injury using Chemical Exchange Saturation Transfer (CEST)-weighted MRI. Sci Rep 8:669
Bryant Jr, L Henry; Kim, Saejeong J; Hobson, Matthew et al. (2017) Physicochemical characterization of ferumoxytol, heparin and protamine nanocomplexes for improved magnetic labeling of stem cells. Nanomedicine 13:503-513
Lim, Jongdoo; Turkbey, Baris; Bernardo, Marcelino et al. (2012) Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics. Bioconjug Chem 23:2291-9
Kojima, Chie; Turkbey, Baris; Ogawa, Mikako et al. (2011) Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics. Nanomedicine 7:1001-8
Xing, Ruijun; Liu, Gang; Quan, Qimeng et al. (2011) Functional MnO nanoclusters for efficient siRNA delivery. Chem Commun (Camb) 47:12152-4
Xing, Ruijun; Zhang, Fan; Xie, Jin et al. (2011) Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI. Nanoscale 3:4943-5
Nwe, Kido; Milenic, Diane; Bryant, L Henry et al. (2011) Preparation, characterization and in vivo assessment of Gd-albumin and Gd-dendrimer conjugates as intravascular contrast-enhancing agents for MRI. J Inorg Biochem 105:722-7
Ogawa, Mikako; Regino, Celeste A S; Marcelino, Bernardo et al. (2010) New nanosized biocompatible MR contrast agents based on lysine-dendri-graft macromolecules. Bioconjug Chem 21:955-60

Showing the most recent 10 out of 11 publications