Abstract

The Section of General Surgical Pathology provides clinical surgical pathology diagnostic services to the NIH Clinical Center, and thereby to the entire NIH community. The diagnostic modalities utilized include hematoxylin and eosin-based histology, and adjunct studies such as immunohistochemistry, molecular genetic studies, and tissue-based fluorescence in situ hybridization. The breadth of disease processes encountered by clinicians in this Section is wide, and includes cancer, benign tumors, infectious diseases, degenerative diseases and the aging process, developmental disorders, diseases of the heart and circulatory system, and genetic diseases. Many of the specimens evaluated derive from unique populations of patients with rare or even undiagnosed diseases. Accordingly these clinical tissues from biopsies and surgical resections, along with the corresponding patient clinical information, comprise a resource rich for collaborative research projects for the clinical staff in the Section. In addition, they are utilized as an essential component in the training of Anatomic Pathology residents in the Laboratory of Pathology's well-regarded ACGME-accredited Training Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDBC011291-03
Application #
8554179
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2012
Total Cost
$2,033,932
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Inaguma, Shingo; Lasota, Jerzy; Wang, Zengfeng et al. (2017) Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas. Mod Pathol 30:278-285
Quadri, Humair S; Aiken, Taylor J; Allgaeuer, Michael et al. (2017) Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer. BMC Cancer 17:495
Levy, Angela D; Manning, Maria A; Miettinen, Markku M (2017) Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas. Radiographics 37:797-812
Zhang, Jingli; Khanna, Swati; Jiang, Qun et al. (2017) Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient-Derived Xenografts and Mesothelin as a Biomarker of Tumor Response. Clin Cancer Res 23:1564-1574
Inaguma, Shingo; Wang, Zengfeng; Lasota, Jerzy et al. (2017) Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma. Oncotarget 8:26744-26754
Lasota, Jerzy; Kowalik, Artur; Felisiak-Golabek, Anna et al. (2017) SP174, NRAS Q61R Mutant-Specific Antibody, Cross-Reacts With KRAS Q61R Mutant Protein in Colorectal Carcinoma. Arch Pathol Lab Med 141:564-568
Pandey, Puspa R; Chatterjee, Bishwanath; Olanich, Mary E et al. (2017) PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma. J Pathol 241:626-637
Miettinen, Markku M; Antonescu, Cristina R; Fletcher, Christopher D M et al. (2017) Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview. Hum Pathol 67:1-10
Levy, Angela D; Manning, Maria A; Al-Refaie, Waddah B et al. (2017) Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1-Common Sarcomas: From the Radiologic Pathology Archives. Radiographics 37:462-483
Koczkowska, Magdalena; Lipska-Zi?tkiewicz, Beata Stefania; Iliszko, Mariola et al. (2017) Application of high-resolution genomic profiling in the differential diagnosis of liposarcoma. Mol Cytogenet 10:7

Showing the most recent 10 out of 30 publications