In this award, supported by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. John T. Gerig of the University of California, Santa Barbara will conduct research with his student and postdoctoral colleagues, studying the interactions of small molecules with peptides, and the ways in which these small molecules drive conformational changes in the peptides. The research will be carried out through nuclear magnetic resonance measurement of intermolecular NOE signals, coupled with molecular dynamics simulations. Ultimately, the data garnered in these studies may fing applications towards extending the shelf-life of peptide based drugs (e.g. insulin) and in industrial processes that employ enzymes.

Besides the broader scientific impact of the research, the research will result in the training student and post-doctoral researchers in a combined experimental and theoretical research program. Results of the research will be made available to the public on a website.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Type
Standard Grant (Standard)
Application #
0408415
Program Officer
Charles D. Pibel
Project Start
Project End
Budget Start
2004-08-15
Budget End
2009-07-31
Support Year
Fiscal Year
2004
Total Cost
$360,000
Indirect Cost
Name
University of California Santa Barbara
Department
Type
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106