Abstract

The objective of the core technology development activity is to provide the necessary chips, chip packaging, and instrumentation in order to support the investigations described in each of the program projects and the User Center. This development effort is specifically directed at strategies for use of DNA chips in high throughput genome projects including SBH and mapping.
The specific aim i s to develop microtiter- based versions of our chip format and reader instrumentation for use in automated liquid handling instruments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Program Projects (P01)
Project #
5P01HG001323-02
Application #
5213046
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Lee, Albert; Henras, Anthony K; Chanfreau, Guillaume (2005) Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae. Mol Cell 19:39-51
Danin-Kreiselman, Michal; Lee, Chrissie Young; Chanfreau, Guillaume (2003) RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell 11:1279-89
Patti, Mary Elizabeth; Butte, Atul J; Crunkhorn, Sarah et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 100:8466-71
Zheng, Z; Venkatapathy, S; Rao, G et al. (2002) Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. Leukemia 16:2429-37
Schulze, A; Lehmann, K; Jefferies, H B et al. (2001) Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev 15:981-94
Soulez, M; Parker, M G (2001) Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling. J Mol Endocrinol 27:259-74
Nadler, S T; Stoehr, J P; Schueler, K L et al. (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci U S A 97:11371-6
Gentalen, E; Chee, M (1999) A novel method for determining linkage between DNA sequences: hybridization to paired probe arrays. Nucleic Acids Res 27:1485-91
Sapolsky, R J; Hsie, L; Berno, A et al. (1999) High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays. Genet Anal 14:187-92
Lelivelt, M J; Culbertson, M R (1999) Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome. Mol Cell Biol 19:6710-9

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