Abstract

The objective of the core technology development activity is to provide the necessary chips, chip packaging, and instrumentation in order to support the investigations described in each of the program projects and the User Center. This development effort is specifically directed at strategies for use of DNA chips in high throughput genome projects including SBH and mapping.
The specific aim i s to develop microtiter- based versions of our chip format and reader instrumentation for use in automated liquid handling instruments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Program Projects (P01)
Project #
5P01HG001323-03
Application #
6109114
Study Section
Project Start
1997-09-30
Project End
1999-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Affymetrix, Inc.
Department
Type
DUNS #
804682573
City
Santa Clara
State
CA
Country
United States
Zip Code
95051

  Publications

Lee, Albert; Henras, Anthony K; Chanfreau, Guillaume (2005) Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae. Mol Cell 19:39-51
Danin-Kreiselman, Michal; Lee, Chrissie Young; Chanfreau, Guillaume (2003) RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell 11:1279-89
Patti, Mary Elizabeth; Butte, Atul J; Crunkhorn, Sarah et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 100:8466-71
Zheng, Z; Venkatapathy, S; Rao, G et al. (2002) Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. Leukemia 16:2429-37
Schulze, A; Lehmann, K; Jefferies, H B et al. (2001) Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev 15:981-94
Soulez, M; Parker, M G (2001) Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling. J Mol Endocrinol 27:259-74
Nadler, S T; Stoehr, J P; Schueler, K L et al. (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci U S A 97:11371-6
Hacia, J G; Fan, J B; Ryder, O et al. (1999) Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet 22:164-7
Gentalen, E; Chee, M (1999) A novel method for determining linkage between DNA sequences: hybridization to paired probe arrays. Nucleic Acids Res 27:1485-91
Sapolsky, R J; Hsie, L; Berno, A et al. (1999) High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays. Genet Anal 14:187-92

Showing the most recent 10 out of 17 publications