The hypothesis underlying the work proposed in this application is that a further understanding of MIS downstream signalling will be useful in elucidating the role of this molecule during development, and potentially in new therapeutics for the treatment of tumors that express the MIS receptor. The applicants propose that: """"""""MIS will bind its type II receptor to activate its type I receptor, which in turn will activate a downstream signal cascade, leading to growth arrest and/or death."""""""" The applicants will focus in this project on the MIS specific type 1 receptor. The specific objectives of this application are to: 1) identify the MIS specific type 1 receptor; 2) analyze the role of the MIS type 1 receptor in vivo, using viral vectors, transgenic mice and/or conditional knockout mice; 3) characterize MIS downstream signalling; and 4) identify the target genes regulated by MIS.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD032112-06A1
Application #
6042741
Study Section
Reproductive Biology Study Section (REB)
Program Officer
Taymans, Susan
Project Start
1994-08-01
Project End
2004-12-31
Budget Start
2000-01-15
Budget End
2000-12-31
Support Year
6
Fiscal Year
2000
Total Cost
$272,210
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
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Arango, Nelson A; Szotek, Paul P; Manganaro, Thomas F et al. (2005) Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium. Dev Biol 288:276-83
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