This competing continuation is part of a 2-site collaborative research grant with an identical application submitted concurrently by Dr. Lyn Y. Abramson at the University of Wisconsin. Prior research did not provide an adequate test of the hopelessness theory (HT) and Beck's theory (BT) of depression and may have been misleading about those cognitive theories' validity. Thus, the overarching goal of this project is to provide a more powerful test of HT's and BT's predictions about the etiology of depression and a validation of the Hopelessness Depression subtype. To this end, a large scale, 5.5-year prospective study was conducted at both sites. Initially nondepressed, non-psychopathological Ss (n=349) who were at either high or low cognitive risk for depression were followed prospectively with independent and blind self-report and interview assessments of stressful life events, cognitions, social support, coping, and psychiatric status/symptoms in order to predict onsets and subsequent recurrences of depression. Familial and developmental origins of cognitive vulnerability to depression were also examined, including assessment of the parents(n=335) of high-risk and low-risk Ss. In this renewal, differential predictors of first onsets vs. recurrences of depression, factors that increase resilience among high-risk Ss and promote depression among low-risk Ss, factors that mediate and moderate change in cognitive vulnerability, and different models of cognitive vulnerability-stress relations are also investigated. This project contributes to: 1) the scientific understanding of the etiology and course of a subset of the mood disorders; 2) a more valid nosology of the depressive disorders; 3) an understanding of the origins and continuity/change of cognitive vulnerability to depression; 4) an understanding of factors that promote resilience to depression; and 5) the development of interventions for treating and preventing depression.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH048216-10
Application #
6437987
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Dolan-Sewell, Regina
Project Start
1990-09-01
Project End
2003-12-31
Budget Start
2002-01-10
Budget End
2002-12-31
Support Year
10
Fiscal Year
2002
Total Cost
$134,542
Indirect Cost
Name
Temple University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Shapero, Benjamin G; Hamilton, Jessica L; Stange, Jonathan P et al. (2015) Moderate Childhood Stress Buffers Against Depressive Response to Proximal Stressors: A Multi-Wave Prospective Study of Early Adolescents. J Abnorm Child Psychol 43:1403-1413
Shapero, Benjamin G; Black, Shimrit K; Liu, Richard T et al. (2014) Stressful life events and depression symptoms: the effect of childhood emotional abuse on stress reactivity. J Clin Psychol 70:209-23
Liu, Richard T; Jager-Hyman, Shari; Wagner, Clara A et al. (2012) Number of childhood abuse perpetrators and the occurrence of depressive episodes in adulthood. Child Abuse Negl 36:323-32
Liu, Richard T; Alloy, Lauren B (2010) Stress generation in depression: A systematic review of the empirical literature and recommendations for future study. Clin Psychol Rev 30:582-93
Iacoviello, Brian M; Alloy, Lauren B; Abramson, Lyn Y et al. (2010) The early course of depression: a longitudinal investigation of prodromal symptoms and their relation to the symptomatic course of depressive episodes. J Abnorm Psychol 119:459-67
Rood, Lea; Roelofs, Jeffrey; Bögels, Susan M et al. (2010) Dimensions of Negative Thinking and the Relations with Symptoms of Depression and Anxiety in Children and Adolescents. Cognit Ther Res 34:333-342
Smith, Jeannette M; Alloy, Lauren B (2009) A roadmap to rumination: a review of the definition, assessment, and conceptualization of this multifaceted construct. Clin Psychol Rev 29:116-28
Roelofs, Jeffrey; Rood, Lea; Meesters, Cor et al. (2009) The influence of rumination and distraction on depressed and anxious mood: a prospective examination of the response styles theory in children and adolescents. Eur Child Adolesc Psychiatry 18:635-42
Liu, Richard T; Alloy, Lauren B; Abramson, Lyn Y et al. (2009) Emotional maltreatment and depression: prospective prediction of depressive episodes. Depress Anxiety 26:174-81
Romens, Sara E; Abramson, Lyn Y; Alloy, Lauren B (2009) High and Low Cognitive Risk For Depression: Stability From Late Adolescence to Early Adulthood. Cognit Ther Res 33:480-498

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