Cyclic Nucleotides in Cone Metabolism and Disease

Farber, Debora B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Eye Institute (NEI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 4R37EY002651-19
• Application #: 2158486
• Study Section: Special Emphasis Panel (NSS)
• Project Start: 1978-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 19
• Fiscal Year: 1996

Institution

• Name: University of California Los Angeles
• Department: Ophthalmology
• Type: Schools of Medicine
• DUNS #: 119132785
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90095

Publications

Verardo, Mark R; Viczian, Andrea; Piri, Natik et al. (2009) Regulatory sequences in the 3' untranslated region of the human cGMP-phosphodiesterase beta-subunit gene. Invest Ophthalmol Vis Sci 50:2591-8

Gao, Yong-Qing; Danciger, Michael; Ozgul, Riza Koksal et al. (2007) Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. Mol Vis 13:287-92

Tsang, S H; Woodruff, M L; Janisch, Kerstin M et al. (2007) Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response. J Physiol 579:303-12

Lerner, Leonid E; Piri, Natik; Farber, Debora B (2006) Transcriptional and post-transcriptional regulation of the rod cGMP-phosphodiesterase beta-subunit gene. Recent advances and current concepts. Adv Exp Med Biol 572:217-29

Tsang, Steven H; Woodruff, Michael L; Chen, Ching-Kang et al. (2006) GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. J Neurosci 26:4472-80

Linberg, Kenneth A; Fariss, Robert N; Heckenlively, John R et al. (2005) Morphological characterization of the retinal degeneration in three strains of mice carrying the rd-3 mutation. Vis Neurosci 22:721-34

Piri, Natik; Gao, Yong Qing; Danciger, Michael et al. (2005) A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy. Ophthalmology 112:159-66

Viczian, A S; Verardo, M; Zuber, M E et al. (2004) Conserved transcriptional regulation of a cone phototransduction gene in vertebrates. FEBS Lett 577:259-64

Piriev, Natik I; Yamashita, Clyde K; Shih, Jennifer et al. (2003) Expression of cone photoreceptor cGMP-phosphodiesterase alpha' subunit in Chinese hamster ovary, 293 human embryonic kidney, and Y79 retinoblastoma cells. Mol Vis 9:80-6

Piri, Natik; Yamashita, Clyde K; Shih, Jennifer et al. (2003) Differential expression of rod photoreceptor cGMP-phosphodiesterase alpha and beta subunits: mRNA and protein levels. J Biol Chem 278:36999-7005