Abstract

The Stanford Unit is part of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreas Cancer (CPDPC), which has 4 signature protocols including the PROCEED, INSPIRRE2, DETECT, and NOD study. Our Clinical Center has actively enrolled participants in all 4 studies. The purpose of this administrative supplement request is to increase enrollment primarily in the NOD and secondarily in the DETECT studies by adding an additional full-time Clinical Research Coordinator to boost enrollment of participants and a part-time Laboratory Science Technician to help process and bank samples according to the current protocols.

Public Health Relevance

Chronic pancreatitis has no cure, is associated with significant disability, and a higher risk of diabetes and pancreas cancer. By aligning our resources with several other clinical centers to form a consortium, we propose to pursue further studies regarding the role of the immune and hormonal system in chronic pancreatitis. These may lead to new insights into understanding how chronic pancreatitis progresses and complications develop including diabetes and pancreas cancer. New diagnostic tests and treatments can subsequently be developed and then validated by this consortium. This administrative supplement is to increase enrollment by hiring additional clinical and laboratory research staff.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK108300-05S1
Application #
9983467
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Unalp-Arida, Aynur
Project Start
2015-09-28
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Eibl, Guido; Cruz-Monserrate, Zobeida; Korc, Murray et al. (2018) Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. J Acad Nutr Diet 118:555-567
Serrano, Jose; Andersen, Dana K; Forsmark, Christopher E et al. (2018) Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer: From Concept to Reality. Pancreas 47:1208-1212
Forsmark, Christopher E; Andersen, Dana K; Farrar, John T et al. (2018) Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Chronic Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas 47:1200-1207
Fisher, William E; Cruz-Monserrate, Zobeida; McElhany, Amy L et al. (2018) Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 47:1213-1221
Uc, Aliye; Perito, Emily R; Pohl, John F et al. (2018) INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 47:1222-1228
Hart, Phil A; Andersen, Dana K; Mather, Kieren J et al. (2018) Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis Pancreas 47:1239-1243
Abbruzzese, James L; Andersen, Dana K; Borrebaeck, Carl A K et al. (2018) The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas 47:516-525
Lee, Linda S; Andersen, Dana K; Ashida, Reiko et al. (2017) EUS and related technologies for the diagnosis and treatment of pancreatic disease: research gaps and opportunities-Summary of a National Institute of Diabetes and Digestive and Kidney Diseases workshop. Gastrointest Endosc 86:768-778
Park, Walter G; Habtezion, Aida (2017) Editors' Introduction to the Chronic Pancreatitis and Pancreatic Cysts Special Issue. Dig Dis Sci 62:1681-1682
Lee, Jonghyeob; Snyder, Emily R; Liu, Yinghua et al. (2017) Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nat Commun 8:14686

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