for Randomized COVID-19 Testing in Vulnerable Communities and Risk Tool Creation The broad objective of this project is first to perform community-engaged research using randomized COVID-19 tests among vulnerable populations in Milwaukee County, Wisconsin, and then to use innovative empirical methods to measure infection rates and progression risk, if infected, from symptomatic infection, to hospitalization, ICU admission, and death. This project is part of the NIH RADx-UP initiative to transform health through research and discovery in COVID testing among underserved populations. The 2-year project has three specific aims.
Aim 1 : Use randomized COVID antibody testing of more than 23,000 persons to measure the population proportion infected with COVID and how this proportion varies over time and with patient health and demographic characteristics. Twelve partner primary care health centers and 150 churches will support community engagement to achieve target enrollments for low-income, minority and elderly populations. These populations will be oversampled to obtain more precise estimates for these high-risk groups.
Aim 2 : Use extensive data linkages to health care data, virus testing data, and mortality records to estimate infection rates and progression risks as a multivariate function of patient and community characteristics. A web-based risk assessment tool in English and Spanish will be created to allow individuals, families, and health care professionals to assess individual progression risk and household transmission risk and to advise individuals on risk mitigation. This risk assessment tool will be informed by the Milwaukee data and will be of value nationwide.
Aim 3 : When COVID vaccines become available, the risk assessment tool will be used to inform the prioritization of vaccination of higher risk individuals. Established trusting relationships with primary care health centers and churches that serve vulnerable populations, social media outreach, community interest in COVID antibody test results, and easily accessed web-based consents, surveys, and risk assessment tools, as well as Community Advisory Board and focus groups input, will foster successful participation in this project. Random sampling methods will be used to estimate the population proportion infected as a function of demographic and health characteristics accounting for the potential for COVID virus testing, antibody testing, or both, to result in false negative test results. Population-representative estimates will be adjusted to account for oversampling of elderly, minority, and low-income populations, and for differences in response rates to the testing offers. To estimate progression risk, the tested population will be used to create a ?synthetic? Milwaukee. This synthetic Milwaukee information will be combined with data on deceased patients and hospitalized patients to estimate progression risks. Core empirical methods innovations include: 1) estimating the proportion of persons who are antibody negative, and either were not virus tested or were virus negative, as a function of personal and community characteristics, in order to develop a more complete measure of the infection rate; 2) using the tested subsample to create a synthetic Milwaukee which can be combined with actual data on hospitalized and deceased patients to estimate progression risks, and using multiple imputation methods to correctly estimate the uncertainty in defining the synthetic Milwaukee.

Public Health Relevance

Our community is in need of better preventive measures, more accurate diagnostics and more effective and efficient therapies. We offer a novel and comprehensive mechanism to address this need through research and education. We propose to create a mutually learning ecosystem that coalesce a myriad of requisite stakeholders including health systems, research enterprises and the community in southeast Wisconsin to work in tandem towards solutions that improve the health outcomes of our citizens.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001436-06S1
Application #
10232782
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Rosemond, Erica K
Project Start
2020-09-24
Project End
2025-05-31
Budget Start
2020-09-24
Budget End
2021-05-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Egner, John M; Jensen, Davin R; Olp, Michael D et al. (2018) Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy. Chembiochem 19:448-458
May, Meghan; Brousseau, David C; Nelson, David A et al. (2018) Why Parents Seek Care for Acute Illness in the Clinic or the ED: The Role of Health Literacy. Acad Pediatr 18:289-296
Deering, Rita E; Cruz, Meredith; Senefeld, Jonathon W et al. (2018) Impaired Trunk Flexor Strength, Fatigability, and Steadiness in Postpartum Women. Med Sci Sports Exerc 50:1558-1569
Widlansky, Michael E; Jensen, David M; Wang, Jingli et al. (2018) miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. EMBO Mol Med 10:
Ma, Hongfeng; Gros, Eric; Szabo, Aniko et al. (2018) Evaluation of motion artifact metrics for coronary CT angiography. Med Phys 45:687-702
Malik, Mobin; Suboc, Tisha M; Tyagi, Sudhi et al. (2018) Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res 123:1091-1102
Agrawal, D; Kern, M; Edeani, F et al. (2018) Swallow strength training exercise for elderly: A health maintenance need. Neurogastroenterol Motil 30:e13382
Lapierre-Landry, Maryse; Huckenpahler, Alison L; Link, Brian A et al. (2018) Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. Transl Vis Sci Technol 7:4
Patterson, Emily J; Kalitzeos, Angelos; Kasilian, Melissa et al. (2018) Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations. Invest Ophthalmol Vis Sci 59:4238-4248
Pearce, Jean I; Brousseau, David C; Yan, Ke et al. (2018) Behavioral Changes in Children After Emergency Department Procedural Sedation. Acad Emerg Med 25:267-274

Showing the most recent 10 out of 90 publications