The successful and rapid translation of fundamental discoveries into better health for our citizens requires a clinical and translational science network that is robust, multidisciplinary, and national in scope. The mission of the Clinical and Translational Science Institute of Southeastern Wisconsin, a unique academic- community partnership between five area academic institutions and three hospitals, is to develop an integrated, shared home for clinical and translational research and research training, hallmarked by a borderless, collaborative, synergistic, and investigator/community/patient-friendly research environment that is functionally integrated into regional and national CTSA networks with the goal of enhancing the transit of therapeutic, diagnostic, and preventive interventions along the developmental pipeline. In the initial five years following the creation of our CTSI, remarkable progress has been made in the multilevel integration of the eight area institutions that comprise the CTSI, the creation of cross-institutional masters and doctoral programs in clinical and translational science, the formation of a bioinformatics focus on clinical and translational research, the development of an increasingly penetrant infrastructure that supports and facilitates the performance of clinical and translational research, including biostatics and trial design and execution, regulatory compliance, translational unit support, and integration into the regional community. Following this initial success, CTSA2.0 proposes to 1) empower our CTSA hub to play a major role in the clinical and research agenda of the nation, by engaging with regional and national CTSA networks in multi-site studies, expanding our partnership to involve additional NIH, NSF, and industry-funded centers and programs, and identifying and replacing bottlenecks and inefficiencies in our clinical and translational research enterprise with innovative and effective solutions; 2) maximize the translational capability and impact of our CTSA hub and its investigators, through the expanded development of a translational workforce trained in team science, engagement of communities of stakeholders in our communities, catalyzing multi-disciplinary team science using innovative approaches, and delivering efficient and timely services to support the conduct of high quality and safe research; and 3) create a mutual learning ?health-care enterprise-CTSA-eco system? that broadens the range and influence of our translational research engine to involve new health systems and patient stakeholder in generating and testing hypotheses, by completing and operationalizing our Biomedical Informatics Connectome which links clinical data in our health systems to our clinical data warehouse that is accessible to investigators and stakeholders, integrating research into clinical practices of our health systems, and providing the opportunity to every patient to benefit from and contribute to advancing health through participation in translational research. These goals and program relates directly to the NIH mission for the CTSAs ? to remove impediments to the translation of fundamental discoveries into better health for our citizens

Public Health Relevance

Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the discoveries into better health for our citizens.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001436-05
Application #
9688260
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Jones, Patricia L
Project Start
2015-08-18
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2021-03-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Hyngstrom, Allison S; Murphy, Spencer A; Nguyen, Jennifer et al. (2018) Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study. J Appl Physiol (1985) 124:1140-1147
Lerma, Nicholas L; Cho, Chi C; Swartz, Ann M et al. (2018) Isotemporal Substitution of Sedentary Behavior and Physical Activity on Function. Med Sci Sports Exerc 50:792-800
Knight, Jennifer M; Kerswill, Stephanie A; Hari, Parameswaran et al. (2018) Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation. BMC Cancer 18:593
Jim, Heather S L; Sutton, Steven; Majhail, Navneet S et al. (2018) Severity, course, and predictors of sleep disruption following hematopoietic cell transplantation: a secondary data analysis from the BMT CTN 0902 trial. Bone Marrow Transplant 53:1038-1043
Turcotte, Lucie M; Wang, Tao; Hemmer, Michael T et al. (2018) Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation. Bone Marrow Transplant 53:932-937
Lee, Daniel J; Woertz, Erica N; Visotcky, Alexis et al. (2018) The Henle Fiber Layer in Albinism: Comparison to Normal and Relationship to Outer Nuclear Layer Thickness and Foveal Cone Density. Invest Ophthalmol Vis Sci 59:5336-5348
Spellecy, Ryan; Eve, Ann Marie; Connors, Emily R et al. (2018) The Real-Time IRB: A Collaborative Innovation to Decrease IRB Review Time. J Empir Res Hum Res Ethics 13:432-437
Strampe, Margaret R; Huckenpahler, Alison L; Higgins, Brian P et al. (2018) Intraobserver Repeatability and Interobserver Reproducibility of Ellipsoid Zone Measurements in Retinitis Pigmentosa. Transl Vis Sci Technol 7:13
Skinner, Nathan P; Lee, Seung-Yi; Kurpad, Shekar N et al. (2018) Filter-probe diffusion imaging improves spinal cord injury outcome prediction. Ann Neurol 84:37-50
Morrison, Andrea K; Myrvik, Matthew P; Brousseau, David C et al. (2018) Parents' pain medication underdosing is associated with more emergency department visits in sickle cell disease. Pediatr Blood Cancer 65:

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