Abstract

Both hypothyroid and hyperthyroid patients have been reported to be associated with an increased incidence of atherothrombotic events. We completed analysis of thyroid function tests, serum lipid parameters (with special respect to lipoprotein[a]) and various hemostatic parameters in previously thyroidectomized patients who underwent thyroid scan for follow-up of their thyroid cancer. At that time, the patients change their thyroid status from hyperthyroid (due to thyroid hormone suppression therapy) to temporarily hypothyroid (due to discontinuation of thyroid hormone suppression therapy.) The blood specimens obtained during these phases represent primarily systemic thyroid hormone effects as opposed to underlying diseases with confounding effects of inflammation, etc., in primary hypothyroidism and hyperthyroidism. Since all previous studies compared different groups of hypothyroid and hyperthyroid patients, the results obtained in our studies with the same patients in different thyroid status are expected to provide a clearer understanding of the effect of thyroid hormones on components of atherothrombosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010305-05
Application #
6825472
Study Section
(DLM)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Celi, Francesco S; Zemskova, Marina; Linderman, Joyce D et al. (2009) The pharmacodynamic equivalence of levothyroxine and liothyronine. A randomized, double blind, cross-over study in thyroidectomized patients. Clin Endocrinol (Oxf) :
Bowen, Raffick A R; Vu, Chi; Remaley, Alan T et al. (2007) Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents. Clin Chim Acta 378:181-93
Eisenhofer, Graeme; Lenders, Jacques W M; Goldstein, David S et al. (2005) Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines. Clin Chem 51:735-44
Bowen, Raffick A R; Chan, Yung; Ruddel, Mark E et al. (2005) Immunoassay interference by a commonly used blood collection tube additive, the organosilicone surfactant silwet L-720. Clin Chem 51:1874-82
Bowen, Raffick A R; Chan, Yung; Cohen, Joshua et al. (2005) Effect of blood collection tubes on total triiodothyronine and other laboratory assays. Clin Chem 51:424-33
Eisenhofer, Graeme; Goldstein, David S; Sullivan, Patricia et al. (2005) Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. J Clin Endocrinol Metab 90:2068-75
McGriff, Nayahmka J; Csako, Gyorgy; Gourgiotis, Loukas et al. (2002) Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer. Ann Med 34:554-64
Csako, G; McGriff, N J; Rotman-Pikielny, P et al. (2001) Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders. Ann Pharmacother 35:1578-83
Collins, M T; Remaley, A T; Csako, G et al. (2000) Increased levothyroxine requirements presenting as ""inappropriate"" TSH secretion syndrome in a patient with nephrotic syndrome. J Endocrinol Invest 23:383-92
Csako, G; Byrd, D; Wesley, R A et al. (2000) Assessing the effects of thyroid suppression on benign solitary thyroid nodules. A model for using quantitative research synthesis. Medicine (Baltimore) 79:26-Sep

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