Genetic analysis of attention deficit hyperactivity dis.

Muenke, Maximilian

Abstract

A study of the hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder will be undertaken through a genome wide search for loci linked to ADHD. To this end, 700 affected sibling pairs and 100 densely affected multi-generation Hispanic families will be recruited. Participating individuals will undergo a battery of psychological tests and will have blood drawn for the linkage analysis and positional cloning studies that will be used to search for genes associated with ADHD.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Human Genome Research Institute (NHGRI)
• Type: Intramural Research (Z01)
• Project #: 1Z01HG000175-01
• Application #: 6430094
• Study Section: Molecular Genetics B Study Section (MGB)
• Support Year: 1
• Fiscal Year: 2000

Institution

• Name: Human Genome Research
• Country: United States

Publications

Trujillo-Orrego, N; Pineda, D A; Arango, C P et al. (2009) [Attention deficit hyperactivity behavioral phenotype dimensions of adults from Antioquian families using the Wender-Utah Scale -Spanish version] Rev Neurol 48:400-6

Jain, Mahim; Palacio, Luis Guillermo; Castellanos, F Xavier et al. (2007) Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility Loci. Biol Psychiatry 61:1329-39

Russell, Heather F; Wallis, Deeann; Mazzocco, Michele M M et al. (2006) Increased prevalence of ADHD in Turner syndrome with no evidence of imprinting effects. J Pediatr Psychol 31:945-55

Lee, J S; Tartaglia, M; Gelb, B D et al. (2005) Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome. J Med Genet 42:e11

Wattendorf, Daniel J; Muenke, Maximilian (2005) Prader-Willi syndrome. Am Fam Physician 72:827-30

Wattendorf, Daniel J; Muenke, Maximilian (2005) Diagnosis and management of fragile X syndrome. Am Fam Physician 72:111-3

Edison, Robin J; Muenke, Maximilian (2005) Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 352:2759

Wattendorf, Daniel J; Muenke, Maximilian (2005) Fetal alcohol spectrum disorders. Am Fam Physician 72:279-82, 285

Roessler, Erich; Ermilov, Alexandre N; Grange, Dorothy Katherine et al. (2005) A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet 14:2181-8

Edison, Robin J; Muenke, Maximilian (2004) Central nervous system and limb anomalies in case reports of first-trimester statin exposure. N Engl J Med 350:1579-82