Genetics of Attention Deficit Hyperactivity Disorder

Muenke, Maximilian

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage. The next phase of our research on ADHD involves US families with ADHD.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Human Genome Research Institute (NHGRI)
• Type: Intramural Research (Z01)
• Project #: 1Z01HG000175-04
• Application #: 6830467
• Study Section: Molecular Genetics B Study Section (MGB)
• Support Year: 4
• Fiscal Year: 2003

Institution

• Name: Human Genome Research
• Country: United States

Publications

Trujillo-Orrego, N; Pineda, D A; Arango, C P et al. (2009) [Attention deficit hyperactivity behavioral phenotype dimensions of adults from Antioquian families using the Wender-Utah Scale -Spanish version] Rev Neurol 48:400-6

Jain, Mahim; Palacio, Luis Guillermo; Castellanos, F Xavier et al. (2007) Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility Loci. Biol Psychiatry 61:1329-39

Russell, Heather F; Wallis, Deeann; Mazzocco, Michele M M et al. (2006) Increased prevalence of ADHD in Turner syndrome with no evidence of imprinting effects. J Pediatr Psychol 31:945-55

Lee, J S; Tartaglia, M; Gelb, B D et al. (2005) Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome. J Med Genet 42:e11

Wattendorf, Daniel J; Muenke, Maximilian (2005) Prader-Willi syndrome. Am Fam Physician 72:827-30

Wattendorf, Daniel J; Muenke, Maximilian (2005) Diagnosis and management of fragile X syndrome. Am Fam Physician 72:111-3

Edison, Robin J; Muenke, Maximilian (2005) Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 352:2759

Wattendorf, Daniel J; Muenke, Maximilian (2005) Fetal alcohol spectrum disorders. Am Fam Physician 72:279-82, 285

Roessler, Erich; Ermilov, Alexandre N; Grange, Dorothy Katherine et al. (2005) A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet 14:2181-8

McPherson, Elizabeth; Huff, Dale; Dunn, Jeanette et al. (2004) Anomalies of the forebrain with radial limb defects: Garcia-Lurie-Steinfeld syndrome? Birth Defects Res A Clin Mol Teratol 70:537-44