Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage (Arcos-Burgos et al., 2002). The next phase of our research on ADHD involves US families with ADHD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000175-06
Application #
7147956
Study Section
Molecular Genetics B Study Section (MGB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Human Genome Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Trujillo-Orrego, N; Pineda, D A; Arango, C P et al. (2009) [Attention deficit hyperactivity behavioral phenotype dimensions of adults from Antioquian families using the Wender-Utah Scale -Spanish version] Rev Neurol 48:400-6
Jain, Mahim; Palacio, Luis Guillermo; Castellanos, F Xavier et al. (2007) Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility Loci. Biol Psychiatry 61:1329-39
Russell, Heather F; Wallis, Deeann; Mazzocco, Michele M M et al. (2006) Increased prevalence of ADHD in Turner syndrome with no evidence of imprinting effects. J Pediatr Psychol 31:945-55
Lee, J S; Tartaglia, M; Gelb, B D et al. (2005) Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome. J Med Genet 42:e11
Wattendorf, Daniel J; Muenke, Maximilian (2005) Prader-Willi syndrome. Am Fam Physician 72:827-30
Wattendorf, Daniel J; Muenke, Maximilian (2005) Diagnosis and management of fragile X syndrome. Am Fam Physician 72:111-3
Edison, Robin J; Muenke, Maximilian (2005) Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 352:2759
Wattendorf, Daniel J; Muenke, Maximilian (2005) Fetal alcohol spectrum disorders. Am Fam Physician 72:279-82, 285
Roessler, Erich; Ermilov, Alexandre N; Grange, Dorothy Katherine et al. (2005) A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet 14:2181-8
Edison, Robin J; Muenke, Maximilian (2004) Central nervous system and limb anomalies in case reports of first-trimester statin exposure. N Engl J Med 350:1579-82

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