Biomolecular Screening and Alternative Approaches for the National Toxicology Program

Paules, Richard

Abstract

The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAES103318-02
• Application #: 9550224
• Support Year: 2
• Fiscal Year: 2017

Institution

• Name: U.S. National Inst of Environ Hlth Scis

Publications

Li, Ruifang; Grimm, Sara A; Mav, Deepak et al. (2018) Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer. Cell Rep 22:624-637

Merrick, B Alex; Chang, Justin S; Phadke, Dhiral P et al. (2018) HAfTs are novel lncRNA transcripts from aflatoxin exposure. PLoS One 13:e0190992

Bryce, Steven M; Bernacki, Derek T; Smith-Roe, Stephanie L et al. (2018) Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals. Toxicol Sci 162:146-166

Auerbach, Scott S; Xu, Miaofei; Merrick, B Alex et al. (2018) Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure. Toxicol Pathol 46:706-718

Mav, Deepak; Shah, Ruchir R; Howard, Brian E et al. (2018) A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics. PLoS One 13:e0191105

Xia, Menghang; Huang, Ruili; Shi, Qiang et al. (2018) Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environ Health Perspect 126:077010

Myatt, Glenn J; Ahlberg, Ernst; Akahori, Yumi et al. (2018) In silico toxicology protocols. Regul Toxicol Pharmacol 96:1-17

Kleinstreuer, Nicole C; Hoffmann, Sebastian; Alépée, Nathalie et al. (2018) Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *. Crit Rev Toxicol 48:359-374

Dunnick, J K; Pandiri, A R; Merrick, B A et al. (2018) Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice. Toxicol Rep 5:615-624

Smith-Roe, Stephanie L; Swartz, Carol D; Shepard, Kim G et al. (2018) Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells. Environ Mol Mutagen 59:416-426