Abstract

The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES103318-02
Application #
9550224
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Dunnick, J K; Pandiri, A R; Merrick, B A et al. (2018) Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice. Toxicol Rep 5:615-624
Smith-Roe, Stephanie L; Swartz, Carol D; Shepard, Kim G et al. (2018) Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells. Environ Mol Mutagen 59:416-426
Casati, S; Aschberger, K; Barroso, J et al. (2018) Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol 92:611-617
Harrill, Alison H; Lin, Haixia; Tobacyk, Julia et al. (2018) Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury. Exp Biol Med (Maywood) 243:237-247
Clippinger, Amy J; Allen, David; Behrsing, Holger et al. (2018) Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro 52:131-145
Catlin, Natasha R; Collins, Bradley J; Auerbach, Scott S et al. (2018) How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract. Food Chem Toxicol 118:328-339
Wambaugh, John F; Hughes, Michael F; Ring, Caroline L et al. (2018) Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. Toxicol Sci 163:152-169
Delp, Johannes; Gutbier, Simon; Klima, Stefanie et al. (2018) A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays. ALTEX :
Strickland, Judy; Zang, Qingda; Kleinstreuer, Nicole et al. (2018) Integrated decision strategies for skin sensitization hazard. J Appl Toxicol 38:432
Marshall, Lindsay J; Austin, Christopher P; Casey, Warren et al. (2018) Recommendations toward a human pathway-based approach to disease research. Drug Discov Today :

Showing the most recent 10 out of 79 publications