The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.
| Clippinger, Amy J; Allen, David; Behrsing, Holger et al. (2018) Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro 52:131-145 |
| Catlin, Natasha R; Collins, Bradley J; Auerbach, Scott S et al. (2018) How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract. Food Chem Toxicol 118:328-339 |
| Wambaugh, John F; Hughes, Michael F; Ring, Caroline L et al. (2018) Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. Toxicol Sci 163:152-169 |
| Delp, Johannes; Gutbier, Simon; Klima, Stefanie et al. (2018) A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays. ALTEX : |
| Strickland, Judy; Zang, Qingda; Kleinstreuer, Nicole et al. (2018) Integrated decision strategies for skin sensitization hazard. J Appl Toxicol 38:432 |
| Marshall, Lindsay J; Austin, Christopher P; Casey, Warren et al. (2018) Recommendations toward a human pathway-based approach to disease research. Drug Discov Today : |
| Hur, Junguk; Danes, Larson; Hsieh, Jui-Hua et al. (2018) Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform. Mol Inform 37:e1700129 |
| Strickland, Judy; Clippinger, Amy J; Brown, Jeffrey et al. (2018) Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies. Regul Toxicol Pharmacol 94:183-196 |
| Thomas, Russell S; Paules, Richard S; Simeonov, Anton et al. (2018) The US Federal Tox21 Program: A strategic and operational plan for continued leadership. ALTEX 35:163-168 |
| Duncan, Christopher G; Kondilis-Mangum, Hrisavgi D; Grimm, Sara A et al. (2018) Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells. G3 (Bethesda) 8:805-813 |
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