The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.

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1
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2016
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U.S. National Inst of Environ Hlth Scis
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Thomas, Russell S; Paules, Richard S; Simeonov, Anton et al. (2018) The US Federal Tox21 Program: A strategic and operational plan for continued leadership. ALTEX 35:163-168
Duncan, Christopher G; Kondilis-Mangum, Hrisavgi D; Grimm, Sara A et al. (2018) Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells. G3 (Bethesda) 8:805-813
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Merrick, B Alex; Chang, Justin S; Phadke, Dhiral P et al. (2018) HAfTs are novel lncRNA transcripts from aflatoxin exposure. PLoS One 13:e0190992
Bryce, Steven M; Bernacki, Derek T; Smith-Roe, Stephanie L et al. (2018) Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals. Toxicol Sci 162:146-166
Auerbach, Scott S; Xu, Miaofei; Merrick, B Alex et al. (2018) Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure. Toxicol Pathol 46:706-718

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