Abstract

The NTP Biomolecular Screening Branch (BSB) develops and carries out programs in medium and high throughput screening (HTS) of environmental substances for rapid detection of biological activities of significance to toxicology. The BSB specifically administers the NTP HTS program initiative to implement its vision for toxicology in the 21st century; this vision places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES103318-01
Application #
9354105
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Marshall, Lindsay J; Austin, Christopher P; Casey, Warren et al. (2018) Recommendations toward a human pathway-based approach to disease research. Drug Discov Today :
Hur, Junguk; Danes, Larson; Hsieh, Jui-Hua et al. (2018) Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform. Mol Inform 37:e1700129
Strickland, Judy; Clippinger, Amy J; Brown, Jeffrey et al. (2018) Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies. Regul Toxicol Pharmacol 94:183-196
Thomas, Russell S; Paules, Richard S; Simeonov, Anton et al. (2018) The US Federal Tox21 Program: A strategic and operational plan for continued leadership. ALTEX 35:163-168
Duncan, Christopher G; Kondilis-Mangum, Hrisavgi D; Grimm, Sara A et al. (2018) Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells. G3 (Bethesda) 8:805-813
Emond, Claude; DeVito, Michael J; Diliberto, Janet J et al. (2018) The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling. Toxicol Sci 164:218-228
French, John E; Gatti, Daniel M; Morgan, Daniel L et al. (2018) Erratum: ""Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity"". Environ Health Perspect 126:069003
Sykora, Peter; Witt, Kristine L; Revanna, Pooja et al. (2018) Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sci Rep 8:2771
Bell, Shannon M; Chang, Xiaoqing; Wambaugh, John F et al. (2018) In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol In Vitro 47:213-227
Li, Ruifang; Grimm, Sara A; Mav, Deepak et al. (2018) Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer. Cell Rep 22:624-637

Showing the most recent 10 out of 79 publications