Abstract

Protein enzymes known as helicases can separate the two strands of DNA and RNA duplexes. RNA helicases are important for all areas of RNA maintenance including gene regulation and the innate immune response. We are interested in understanding how a particular RNA helicase identifies unique RNAs found in animals during the immune response to viral infection. This mode of RNA identification is likely conserved throughout evolution, and important for understanding how certain viruses that can cause cancer are sensed during host immunity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM086949-02
Application #
7762832
Study Section
Special Emphasis Panel (ZRG1-F08-G (20))
Program Officer
Hagan, Ann A
Project Start
2009-02-01
Project End
2010-11-30
Budget Start
2010-02-01
Budget End
2010-11-30
Support Year
2
Fiscal Year
2010
Total Cost
$43,370
Indirect Cost

  Institution

Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520