Public Health Relevance

The present application will study OEF/OIF/OND Veterans with chronic mild TBI by: 1) applying a single-subject based, voxel-wise, MEG slow-wave (delta-band, 1-4 Hz) source imaging approach for assisting in mild TBI diagnosis, by detecting neuronal abnormalities not visible in conventional MRI; 2) using MEG and behavioral measures to assess the efficacy of a passive neurofeedback treatment in Veterans with mild TBI. The application addresses the following topics under the present RFA: a) The validation and refinement of diagnostic imaging technology for chronic TBI; b) Understanding the relationships between neurobiology and neuropsychological/behavioral effects of chronic TBI; c) Studying the impact of rehabilitation strategies on neural plasticity following TBI, using imaging, neurobiological, and cognitive approaches; and d) Comparisons of pathophysiology and / or treatment of chronic TBI that results from blast injury or other forms of TBI.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
1I01RX001988-01A1
Application #
9395759
Study Section
Brain Injury: TBI & Stroke (RRD1)
Project Start
2018-01-01
Project End
2021-12-31
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
VA San Diego Healthcare System
Department
Type
DUNS #
073358855
City
San Diego
State
CA
Country
United States
Zip Code
92161