The present application will study OEF/OIF/OND Veterans with chronic mild TBI by: 1) applying a single-subject based, voxel-wise, MEG slow-wave (delta-band, 1-4 Hz) source imaging approach for assisting in mild TBI diagnosis, by detecting neuronal abnormalities not visible in conventional MRI; 2) using MEG and behavioral measures to assess the efficacy of a passive neurofeedback treatment in Veterans with mild TBI. The application addresses the following topics under the present RFA: a) The validation and refinement of diagnostic imaging technology for chronic TBI; b) Understanding the relationships between neurobiology and neuropsychological/behavioral effects of chronic TBI; c) Studying the impact of rehabilitation strategies on neural plasticity following TBI, using imaging, neurobiological, and cognitive approaches; and d) Comparisons of pathophysiology and / or treatment of chronic TBI that results from blast injury or other forms of TBI.
|Huang, Ming-Xiong; Nichols, Sharon; Robb-Swan, Ashley et al. (2018) MEG Working Memory N-Back Task Reveals Functional Deficits in Combat-Related Mild Traumatic Brain Injury. Cereb Cortex :|
|Huang, Ming-Xiong; Swan, Ashley Robb; Quinto, Annemarie Angeles et al. (2017) A pilot treatment study for mild traumatic brain injury: Neuroimaging changes detected by MEG after low-intensity pulse-based transcranial electrical stimulation. Brain Inj 31:1951-1963|