Mariana Cherner, PhD, is an Associate Professor of Psychiatry at the University of California San Diego and an NIH-funded neuroAIDS investigator for over 15 years. This is a proposal for a K24 Midcareer Investigator Award in Patient-Oriented Research to increase Dr. Cherner's ability to mentor clinician scientists and bring them into the fold of research at the intersection of neuroAIDS and substance abuse. Dr. Cherner has mentored more than 30 trainees at various career stages, from undergraduates to junior faculty. Greater than half of her mentees have been from underrepresented backgrounds, and a majority are women. With support from the proposed K24 award, Dr. Cherner would be able to expand her mentoring efforts and maintain a special focus on attracting trainees from backgrounds that are not well-represented in academic medicine. During the proposed award, Dr. Cherner plans to provide mentoring in her current areas of research, broadly (1) individual differences in vulnerability to methamphetamine-related brain dysfunction in the context of HIV, and (2) cross-cultural applications of neuropsychological methods to detect effects of HIV and substance abuse in diverse populations. This work will be supported by her own funded grants as well as by her participation in large projects within the HIV Neurobehavioral Research Program (HNRP) at UCSD, which include all the major neuro-oriented HIV studies at UCSD such as the Translational Methamphetamine AIDS Research Center (TMARC), the HIV Neurobehavioral Research Center (HNRC), a T32 grant for Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN), and the R25 Interdisciplinary Research Fellowship in NeuroAIDS, which she directs. This superb team-science research environment, along with resources from the Psychiatry Department and the larger UCSD campus, affords excellent opportunities to attract highly qualified trainees and provide rich training experiences for early career patient-oriented researcher. Support from the K24 award would enable Dr. Cherner to reduce administrative and clinical duties to focus the majority of her effort on research mentoring and furthering her research program.

Public Health Relevance

Mariana Cherner, PhD, is neuroAIDS researcher who proposes a K24 Midcareer Investigator Award in Patient- Oriented Research to increase her ability to mentor patient-oriented scientists interested in intersection of neuroAIDS and substance abuse. Support from the K24 award would enable Dr. Cherner to reduce administrative and clinical duties to focus the majority of her effort on research mentoring and furthering her research program.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA040550-02
Application #
9098680
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Lin, Yu
Project Start
2015-07-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
de Almeida, Sérgio Monteiro; de Pereira, Ana Paula; Pedroso, Maria Lucia Alves et al. (2018) Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil. J Neurovirol 24:339-349
Jumare, Jibreel; Ndembi, Nicaise; El-Kamary, Samer S et al. (2018) Cognitive Function Among Antiretroviral Treatment-Naive Individuals Infected With Human Immunodeficiency Virus Type 1 Subtype G Versus CRF02_AG in Nigeria. Clin Infect Dis 66:1448-1453
Marquine, María J; Heaton, Anne; Johnson, Neco et al. (2018) Differences in Neurocognitive Impairment Among HIV-Infected Latinos in the United States. J Int Neuropsychol Soc 24:163-175
de Almeida, Sérgio Monteiro; Kamat, Rujvi; Cherner, Mariana et al. (2017) Improving Detection of HIV-Associated Cognitive Impairment: Comparison of the International HIV Dementia Scale and a Brief Screening Battery. J Acquir Immune Defic Syndr 74:332-338
Spies, Georgina; Fennema-Notestine, Christine; Cherner, Mariana et al. (2017) Changes in cognitive function in women with HIV infection and early life stress. AIDS Care 29:14-23
Denckla, C A; Consedine, N S; Spies, G et al. (2017) Associations between neurocognitive functioning and social and occupational resilience among South African women exposed to childhood trauma. Eur J Psychotraumatol 8:1394146
Jumare, Jibreel; Sunshine, Sara; Ahmed, Hayat et al. (2017) Peripheral blood lymphocyte HIV DNA levels correlate with HIV associated neurocognitive disorders in Nigeria. J Neurovirol 23:474-482
de Almeida, Sergio Monteiro; Barbosa, Francisco Jaime; Kamat, Rujvi et al. (2016) Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil. J Neurovirol 22:789-798
Kamat, Rujvi; Woods, Steven Paul; Cameron, Marizela V et al. (2016) Apathy is associated with lower mental and physical quality of life in persons infected with HIV. Psychol Health Med 21:890-901
Dan, Jennifer M; Massanella, Marta; Smith, Davey M et al. (2016) Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART. J Acquir Immune Defic Syndr 72:133-7

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