The candidate, a Professor of Medicine at the University of Pittsburgh, is applying for a K24 renewal to further advance her career as a clinical investigator and mentor. Her immediate career objectives are to: 1) expand her research portfolio and further establish herself as a leader on patient-oriented osteoporosis research and 2) grow her mentoring program. Her long term career goals are to become a more active and effective institutional leader in patient-oriented research, to leverage collaboration, and advance the broader discipline of clinical research at the University of Pittsburgh. Accomplishments during the past 4 years include: 1) research: establishment of a highly productive clinical research program focused on osteoporosis diagnosis, pathophysiology, prevention, treatment in older patients and patients with cancer- related bone loss, 2) funding: principal investigator for 4 federally-funded research grants including 2 R01s, a P30 core grant and Department of Defense grant, 3) publication record: 38 original articles with 2/3 as senior or first author, 4) mentoring: trained 29 mentees including junior faculty, fellows, residents, medical students and PhD candidates (five fellows received a Certificate or Masters in our K30 program and twenty seven [93%] remain in academic programs), 5) mentee funding: an R03, a K01, two NCRR CREFF awards and two advisee K23 awards;two K23 and one K12 submitted. For the K24 competitive renewal her research will focus on 1) osteoporosis in nursing home patients with a newly funded R01, 2) cancer-related bone loss in men with prostate cancer with a newly funded Department of Defense grant and 3) prevention of bone loss in older women with breast cancer. Student, resident, fellow, and faculty mentoring will be enhanced by the K30 program, the NIH Clinical Translational Science Award and other career development didactic programs coupled with a strong institutional charge to support patient oriented research. To compliment her long term institutional commitment, she will assume a new leadership role as director of the Clinical Translational Research Center at Braddock (a minority based center) and co-director of the University K23 Mentoring Program. Public Health Relevance: Renewal of this K24 award provides protected time to broaden her clinical research and mentoring activities on target with the NIH mission to foster careers of junior investigators in clinical translational research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK062895-10
Application #
8204465
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2003-01-01
Project End
2012-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
10
Fiscal Year
2012
Total Cost
$179,857
Indirect Cost
$13,323
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Greenspan, Susan L; Wagner, Julie; Nelson, Joel B et al. (2013) Vertebral fractures and trabecular microstructure in men with prostate cancer on androgen deprivation therapy. J Bone Miner Res 28:325-32
Greenspan, Susan L; Perera, Subashan; Nace, David et al. (2012) FRAX or fiction: determining optimal screening strategies for treatment of osteoporosis in residents in long-term care facilities. J Am Geriatr Soc 60:684-90
Greenspan, Sl; Nace, D; Perera, S et al. (2012) Lessons learned from an osteoporosis clinical trial in frail long-term care residents. Clin Trials 9:247-56
Nayak, Smita; Roberts, Mark S; Greenspan, Susan L (2012) Impact of generic alendronate cost on the cost-effectiveness of osteoporosis screening and treatment. PLoS One 7:e32879
Rajakumar, Kumaravel; Holick, Michael F; Jeong, Kwonho et al. (2011) Impact of season and diet on vitamin D status of African American and Caucasian children. Clin Pediatr (Phila) 50:493-502
Xu, WanWan; Perera, Subashan; Medich, Donna et al. (2011) Height loss, vertebral fractures, and the misclassification of osteoporosis. Bone 48:307-11
Nayak, Smita; Roberts, Mark S; Greenspan, Susan L (2011) Cost-effectiveness of different screening strategies for osteoporosis in postmenopausal women. Ann Intern Med 155:751-61
van Londen, G J; Perera, S; Vujevich, K et al. (2011) The impact of an aromatase inhibitor on body composition and gonadal hormone levels in women with breast cancer. Breast Cancer Res Treat 125:441-6
Sullivan, Sarah; Wagner, Julie; Resnick, Neil M et al. (2011) Vertebral fractures and the misclassification of osteoporosis in men with prostate cancer. J Clin Densitom 14:348-53

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