The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine;medical students;and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences. Public Health Relevance: This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.

Public Health Relevance

This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24ES013195-10
Application #
8660687
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Mcallister, Kimberly A
Project Start
2004-07-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Time-location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:349-55
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:341-8
Weuve, Jennifer; Kaufman, Joel D; Szpiro, Adam A et al. (2016) Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults. Environ Health Perspect 124:1000-8
Kaufman, Joel D; Adar, Sara D; Barr, R Graham et al. (2016) Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study. Lancet 388:696-704
Kaufman, Joel D; Spalt, Elizabeth W; Curl, Cynthia L et al. (2016) Advances in Understanding Air Pollution and CVD. Glob Heart 11:343-352
Kim, Daniel Seung; Li, Yatong K; Bell, Griffith A et al. (2016) Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc 5:
Hom, Elizabeth K; Duprez, Daniel A; Jacobs Jr, David R et al. (2016) Comparing Arterial Function Parameters for the Prediction of Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Am J Epidemiol 184:894-901
Sack, Cora S; Jansen, Karen L; Cosselman, Kristen E et al. (2016) Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation. Am J Respir Crit Care Med 193:1000-7
Bergen, Silas; Sheppard, Lianne; Kaufman, Joel D et al. (2016) Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. J R Stat Soc Ser C Appl Stat 65:731-753
Pang, Yuanjie; Peng, Roger D; Jones, Miranda R et al. (2016) Metal mixtures in urban and rural populations in the US: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study. Environ Res 147:356-64

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