Despite extensive research documenting the efficacy of cardiovascular disease (CVD) preventive strategies, these are not uniformly applied across diverse patient populations. The applicant for this Midcareer Investigator Award, Dr. Lori Mosca, has an outstanding record of commitment to patient-oriented research to evaluate gender and ethnic differences in CVD risk, barriers to preventive care, and novel methods to increase patient adherence to national prevention guidelines. She has held an NHLBI National Research Career Award in Preventive Cardiology and an NHLBI Mentored Clinical Scientist Development Grant. The K24 grant will support Dr. Mosca to continue a scientific trajectory directed to mentor the next generation of applied scientists in preventive cardiology and to further refine her research skills related to evaluating interventions to improve lifestyle and outcomes in diverse patients at risk for CVD events. The long-term goal of this project is to increase the number and quality of clinical scientists dedicated to research to improving the quality of CVD preventive care in diverse populations.
The specific aims are to 1) Protect Dr. Mosca's time to mentor and conduct patient-oriented research in CVD prevention while advancing her skills in clinical research focused on quality CVD outcomes through formal courses, 2) Establish a structured mentoring program in patient-oriented CVD prevention research targeted to early career investigators, and 3) Support new research to test the impact of an intervention involving Dr, Mosca to increase adherence to national guidelines for CVD prevention among 370 high risk patients. A proposed clinical trial takes advantage of the infrastructure of an ongoing study to identify family members and visitors of patients hospitalized with CVD that may also be at increased risk of CVD events due to shared genes and/or lifestyle. The primary outcome of the trial is the % of high risk patients that achieve an optimal cholesterol level at 1 year compared to those receiving a control intervention. Other ongoing studies funded by the NIH and foundations will provide an enriched research environment to support the K24 goals. Columbia University is uniquely suited to train clinical scientists in issues related to minority and women's cardiovascular health as many of our studies have nearly 50% participation by these populations. The research and careers supported by this project are expected to have a positive impact on attainment of the Healthy People 2010 lifestyle and CVD prevention.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24HL076346-01A1
Application #
6918168
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (F3))
Program Officer
Cooper, Lawton S
Project Start
2005-07-01
Project End
2010-03-31
Budget Start
2005-07-01
Budget End
2006-03-31
Support Year
1
Fiscal Year
2005
Total Cost
$149,929
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Mochari-Greenberger, Heidi; Mosca, Lori (2015) Racial/Ethnic differences in medication uptake and clinical outcomes among hospitalized cardiovascular patients with hypertension and diabetes. Am J Hypertens 28:106-12
Mochari-Greenberger, Heidi; Mosca, Lori (2015) Differential Outcomes by Race and Ethnicity in Patients with Coronary Heart Disease: A Contemporary Review. Curr Cardiovasc Risk Rep 9:
Aggarwal, Brooke; Pender, Ashley; Mosca, Lori et al. (2015) Factors associated with medication adherence among heart failure patients and their caregivers. J Nurs Educ Pract 5:22-27
Reid, Robert D; McDonnell, Lisa A; Riley, Dana L et al. (2014) Effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease: a randomized trial. CMAJ 186:23-30
Mochari-Greenberger, Heidi; Mosca, Matthew; Aggarwal, Brooke et al. (2014) Caregiver status: a simple marker to identify cardiac surgery patients at risk for longer postoperative length of stay, rehospitalization, or death. J Cardiovasc Nurs 29:12-9
Mochari-Greenberger, Heidi; Towfighi, Amytis; Mosca, Lori (2014) National women's knowledge of stroke warning signs, overall and by race/ethnic group. Stroke 45:1180-2
Garshick, M; Mochari-Greenberger, H; Mosca, L (2014) Reduction in dietary trans fat intake is associated with decreased LDL particle number in a primary prevention population. Nutr Metab Cardiovasc Dis 24:100-6
Mochari-Greenberger, Heidi; Liao, Ming; Mosca, Lori (2014) Racial and ethnic differences in statin prescription and clinical outcomes among hospitalized patients with coronary heart disease. Am J Cardiol 113:413-7
Aggarwal, Brooke; Liao, Ming; Mosca, Lori (2013) Medication adherence is associated with having a caregiver among cardiac patients. Ann Behav Med 46:237-42
Mosca, Lori; Hammond, Gmerice; Mochari-Greenberger, Heidi et al. (2013) Fifteen-year trends in awareness of heart disease in women: results of a 2012 American Heart Association national survey. Circulation 127:1254-63, e1-29

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