The proposed Statistics and Data Management Core for the Program Project will provide the computational and analytic resources for successful data collection, storage, linkage, and analysis for all projects in the Program Project. The proposed core will have a data management component and a statistical analysis component. The proposed core will have both data management portion of the core include: 1) linking existing data from Religious Order Study and the Rush Alzheimer's Disease Core Center with findings from the four proposed projects and 2) providing statistical support for all of the studies carried out by the projects. The statistical responsibilities of the core will include providing advice on study design and statistical programming, and providing methodologic expertise on specific questions arising from the use of multiple measures of cognitive impairment. The research goals of the Program Project present complexities and challenges both in the management and in the analysis of the data. Data management will be complicated because of the large quantity of data in varied formats from separate sites, the multiplicity of variables collected from multiple brain regions and multiple studies within one core. This Core will provide expert support from a statistical research team experienced in the conduct of neuropathological studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014449-15
Application #
8377078
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
2014-01-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
15
Fiscal Year
2012
Total Cost
$232,122
Indirect Cost
$75,283
Name
Rush University Medical Center
Department
Type
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Tiernan, Chelsea T; Combs, Benjamin; Cox, Kristine et al. (2016) Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Exp Neurol 283:318-29
Mufson, Elliott J; Ikonomovic, Milos D; Counts, Scott E et al. (2016) Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behav Brain Res 311:54-69
Rosa, Elyse; Mahendram, Sujeivan; Ke, Yazi D et al. (2016) Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiol Aging 48:135-142
Kirkwood, Caitlin M; MacDonald, Matthew L; Schempf, Tadhg A et al. (2016) Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol 75:175-82
Mufson, Elliott J; Malek-Ahmadi, Michael; Snyder, Noelle et al. (2016) Braak stage and trajectory of cognitive decline in noncognitively impaired elders. Neurobiol Aging 43:101-10
Strupp, Barbara J; Powers, Brian E; Velazquez, Ramon et al. (2016) Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. Curr Alzheimer Res 13:97-106
Mizukami, Katsuyoshi; Akatsu, Hiroyasu; Abrahamson, Eric E et al. (2016) Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology 36:135-45
Gorelick, Philip B; Counts, Scott E; Nyenhuis, David (2016) Vascular cognitive impairment and dementia. Biochim Biophys Acta 1862:860-8
Tiernan, Chelsea T; Ginsberg, Stephen D; Guillozet-Bongaarts, Angela L et al. (2016) Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiol Aging 42:80-90
Beck, John S; Mufson, Elliott J; Counts, Scott E (2016) Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease. Curr Alzheimer Res 13:610-4

Showing the most recent 10 out of 245 publications