The Administrative Core will be responsible for overseeing the daily functions of the Center programs infulfilling the goal of the Center. The Core will provide administrative support, including support for grants andfinancial management; scheduling of meetings and seminars; coordination of activities between the Centerand UCLA academic and administrative bodies and other participating institutions (LA BioMed ResearchInstitute at Harbor-UCLA Medical Center, and the VA Greater Los Angeles Healthcare System-West LosAngeles). The Core will also provide biostatistical support for all research projects and cores, and themanagement of research data and shared data function of the Center. It will have the ultimate responsibilityof managing details of the budget, appropriately filing budgetary information, and will file progress reportsand communicate with NCCAM. The scheduling, dissemination of information, and organization of theCenter Symposium, including the participation of the External Advisory Board, will also be the responsibilitiesof the Administrative Core. Oversight all of the established policies for recruitment of women and minorities,and interaction with other NCCAM Centers for Excellence will also be the responsibilities of theAdministrative Core. The Administrative Core, under the direction of Dr. Vay Liang W. Go, will providesupport as well as oversight of the research projects and cores, and Dr. Gang Li will provide biostatisticalsupport: The research projects are: Project 1 on the effects of phytonutrients and metabolism on pancreaticcancer, Project 2 on how polyphenols regulate lipid inflammatory process in pancreatic cancer, and Project 3on flavonoids in pancreatic carcinogenesis and angiogenesis. The projects will utilize our shared coreresources including the Animal Model Core, Phytonutrient Core, and Metabolomics Core. TheAdministrative Core will also interact and collaborate with key investigators and have access to theiravailable shared resources at UCLA and participating institutions to fulfill the Center's goal to studyphytonutrient mechanisms of action in inflammatory and proliferative diseases of the pancreas. It is our goalto have the results of this investigation characterize the metabolic phenotypes in response to specificphytonutrients and so that it can form the rationale for biologically-based practices in the prevention andtreatment of pancreatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program Projects (P01)
Project #
1P01AT003960-01A1
Application #
7394049
Study Section
Special Emphasis Panel (ZAT1-SM (07))
Project Start
2007-12-01
Project End
2012-11-30
Budget Start
2007-12-01
Budget End
2008-09-29
Support Year
1
Fiscal Year
2007
Total Cost
$118,611
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Yang, Qing; Fung, Wing K; Li, Gang (2018) Sample size determination for jointly testing a cause-specific hazard and the all-cause hazard in the presence of competing risks. Stat Med 37:1389-1401
Wang, Hong; Chen, Xiaolin; Li, Gang (2018) Survival Forests with R-Squared Splitting Rules. J Comput Biol 25:388-395
Somlyai, Gábor; Collins, T Que; Meuillet, Emmanuelle J et al. (2017) Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma. Oncotarget 8:50187-50192
Birtolo, Chiara; Go, Vay Liang W; Ptasznik, Andrzej et al. (2016) Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer. Pancreas 45:21-31
Pham, Hung; Hui, Hongxiang; Morvaridi, Susan et al. (2016) A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells. Biochem Biophys Res Commun 475:295-300
Boros, László G; D'Agostino, Dominic P; Katz, Howard E et al. (2016) Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Med Hypotheses 87:69-74
Varma, Vijayalakshmi; Boros, László G; Nolen, Greg T et al. (2015) Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One-Carbon Cycle Energy Producing Pathway. Metabolites 5:364-85
Vaitheesvaran, B; Xu, J; Yee, J et al. (2015) The Warburg effect: a balance of flux analysis. Metabolomics 11:787-796
Gregson, A L; Wang, X; Injean, P et al. (2015) Staphylococcus via an interaction with the ELR+ CXC chemokine ENA-78 is associated with BOS. Am J Transplant 15:792-9
Lu, Qing-Yi; Zhang, Lifeng; Yee, Jennifer K et al. (2015) Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells. Metabolomics 11:71-80

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