The Proteomics Core supporting the individual research projects within this program project grant proposal is comprised of four principal components: (1) Mass spectrometry based proteomics: (PTM analysis and quantification) (2) New technology implementation (3) Large-scale human ES cell culture (4) Informatics

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM081629-05
Application #
8381279
Study Section
Special Emphasis Panel (ZGM1-GDB-8)
Project Start
2012-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$535,810
Indirect Cost
$82,111
Name
Morgridge Institute for Research, Inc.
Department
Type
DUNS #
012420082
City
Madison
State
WI
Country
United States
Zip Code
53715
Suknuntha, Kran; Ishii, Yuki; Tao, Lihong et al. (2015) Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells. Stem Cell Res 15:678-93
Shortreed, Michael R; Wenger, Craig D; Frey, Brian L et al. (2015) Global Identification of Protein Post-translational Modifications in a Single-Pass Database Search. J Proteome Res 14:4714-20
Ladror, Daniel T; Frey, Brian L; Scalf, Mark et al. (2014) Methylation of yeast ribosomal protein S2 is elevated during stationary phase growth conditions. Biochem Biophys Res Commun 445:535-41
Brumbaugh, Justin; Russell, Jason D; Yu, Pengzhi et al. (2014) NANOG is multiply phosphorylated and directly modified by ERK2 and CDK1 in vitro. Stem Cell Reports 2:18-25
Bailey, Derek J; McDevitt, Molly T; Westphall, Michael S et al. (2014) Intelligent data acquisition blends targeted and discovery methods. J Proteome Res 13:2152-61
Sheynkman, Gloria M; Shortreed, Michael R; Frey, Brian L et al. (2014) Large-scale mass spectrometric detection of variant peptides resulting from nonsynonymous nucleotide differences. J Proteome Res 13:228-40
Sheynkman, Gloria M; Johnson, James E; Jagtap, Pratik D et al. (2014) Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations. BMC Genomics 15:703
Sheynkman, Gloria M; Shortreed, Michael R; Frey, Brian L et al. (2013) Discovery and mass spectrometric analysis of novel splice-junction peptides using RNA-Seq. Mol Cell Proteomics 12:2341-53
Miller, Marcus J; Scalf, Mark; Rytz, Thérèse C et al. (2013) Quantitative proteomics reveals factors regulating RNA biology as dynamic targets of stress-induced SUMOylation in Arabidopsis. Mol Cell Proteomics 12:449-63
Russell, Jason D; Scalf, Mark; Book, Adam J et al. (2013) Characterization and quantification of intact 26S proteasome proteins by real-time measurement of intrinsic fluorescence prior to top-down mass spectrometry. PLoS One 8:e58157

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