Outline of Core Activities I. Provide a sophisticated laboratory assay service dedicated to the particular needs of our investigators, namely, the requirement of small individual sample sizes and significant constraints on total blood volume per experiment available for analysis II. Manage analyses of genomic and epigenetic responses in leukocytes a. Link investigators to existing centers (e.g.. Center for Epigenetics and Metabolism under the leadership of Core B Co-Investigator Dr. Paolo Sassone-Corsi) b. Utilize resources at UCI in Biomedical Informatics and Biostatistics to ensure state-of-the-art analysis of genomic and epigenetic data III. Perform state-of-the-art measurements of leukocyte function including flow cytometry, cell culture, and cytokine production IV. Maintain databases of all stored human and rat blood, tissue, and fluids

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Pediatrics Subcommittee (CHHD)
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University of California Irvine
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Ganesan, Goutham; Cotter, Joshua A; Reuland, Warren et al. (2015) Effect of blood flow restriction on tissue oxygenation during knee extension. Med Sci Sports Exerc 47:185-93
Ashish, Naveen; Bamman, Marcas M; Cerny, Frank J et al. (2015) The clinical translation gap in child health exercise research: a call for disruptive innovation. Clin Transl Sci 8:67-76
Radom-Aizik, Shlomit; Zaldivar Jr, Frank P; Haddad, Fadia et al. (2014) Impact of brief exercise on circulating monocyte gene and microRNA expression: implications for atherosclerotic vascular disease. Brain Behav Immun 39:121-9
Radom-Aizik, Shlomit; Zaldivar, Frank P; Nance, Dwight M et al. (2013) Growth inhibition and compensation in response to neonatal hypoxia in rats. Pediatr Res 74:111-20
Horvath, Peter; Oliver, Stacy R; Ganesan, Goutham et al. (2013) Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes. J Investig Med 61:972-7
Radom-Aizik, Shlomit; Zaldivar, Frank; Haddad, Fadia et al. (2013) Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults. J Appl Physiol (1985) 114:628-36
Radom-Aizik, Shlomit; Zaldivar Jr, Frank; Leu, Szu-Yun et al. (2012) Effects of exercise on microRNA expression in young males peripheral blood mononuclear cells. Clin Transl Sci 5:32-8
Adams, Gregory R; Zaldivar, Frank P; Nance, Dwight M et al. (2011) Exercise and leukocyte interchange among central circulation, lung, spleen, and muscle. Brain Behav Immun 25:658-66
Kodesh, Einat; Zaldivar, Frank; Schwindt, Christina et al. (2011) A rat model of exercise-induced asthma: a nonspecific response to a specific immunogen. Am J Physiol Regul Integr Comp Physiol 300:R917-24
Oliver, Stacy R; Rosa, Jaime S; Minh, Timothy D C et al. (2010) Dose-dependent relationship between severity of pediatric obesity and blunting of the growth hormone response to exercise. J Appl Physiol 108:21-7

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