This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In a cell's nucleus, regions of different chromosomes are often in close contact with one another. In some cases, genetic regulatory elements that are encoded on separate chromosomes can communicate with each other, thereby permitting a form of gene regulation that is dependent upon physical proximity between two chromosomes. Recent technological advances have allowed the genetics community to uncover several examples of such interchromosomal interactions, but our understanding of these phenomena remains incomplete. In this proposal, I aim to better understand interchromosomal gene regulation using Drosophila melanogaster as a model system. Specifically, I will assess interchromosomal interactions between various genetic regulatory elements at different locations in the D. melanogaster genome in order to assess the influence of element identity and local genomic context. In addition, I will extend our understanding of the evolutionary history of interchromosomal gene regulation by asking whether this capacity is conserved in other Drosophila species. Through these studies, I aim to understand parameters governing interchromosomal gene regulation, and to better grasp how the spatial organization of the nucleus impacts gene activation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016463-11
Application #
8360304
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
11
Fiscal Year
2011
Total Cost
$140,567
Indirect Cost
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salsbury Cove
State
ME
Country
United States
Zip Code
04672
Hahn, Mark E; Karchner, Sibel I; Merson, Rebeka R (2017) Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution. Curr Opin Toxicol 2:58-71
Ariyachet, Chaiyaboot; Bei├čel, Christian; Li, Xiang et al. (2017) Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1. Mol Microbiol 104:499-519
Nickerson, Chelsea A; Brown, Alexandra L; Yu, Waylin et al. (2017) Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats. Neuroscience 361:116-128
Wirth, Peter; Yu, Waylin; Kimball, Amanda L et al. (2017) New method to induce mild traumatic brain injury in rodents produces differential outcomes in female and male Sprague Dawley rats. J Neurosci Methods 290:133-144
Mangiamele, Lisa A; Gomez, Julia R; Curtis, Nancy J et al. (2017) GPER/GPR30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (Carassius auratus) and colocalizes with isotocin. J Comp Neurol 525:252-270
Dickinson, Patsy S; Qu, Xuan; Stanhope, Meredith E (2016) Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches. Curr Opin Neurobiol 41:149-157
Palopoli, Michael F; Peden, Colin; Woo, Caitlin et al. (2015) Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes. BMC Evol Biol 15:93
Dickinson, Patsy S; Calkins, Andrew; Stevens, Jake S (2015) Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus. J Neurophysiol 113:856-70
Dickinson, Patsy S; Sreekrishnan, Anirudh; Kwiatkowski, Molly A et al. (2015) Distinct or shared actions of peptide family isoforms: I. Peptide-specific actions of pyrokinins in the lobster cardiac neuromuscular system. J Exp Biol 218:2892-904
McCall, Nora; Mahadevia, Darshini; Corriveau, Jennifer A et al. (2015) Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats. Pharmacol Biochem Behav 132:125-135

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