In this COBRE renewal application, we will further develop a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF) and its partner institutions in Oklahoma. In the initial funding period, we fostered vascular biology research through a multidisciplinary approach. We supported methods development in new core facilities that enhanced the research projects. Mentoring launched the independent careers of outstanding junior investigators, who brought innovative new technologies to OMRF, made possible new multi-investigator NIH grants, and helped us recruit a new cadre of outstanding young investigators with great promise. To date, our nine COBRE project leaders have published 63 papers and received three R01/P01 grants, an NSF grant, and many other grants as PI or project leader. In this renewal, we will exploit synergistic interactions in the Cardiovascular Biology and Free Radical Biology and Aging Programs at OMRF to further develop our vascular biology center. We will support projects of four new junior investigators and one early-to-mid-career investigator. These projects address complementary themes in vascular development, atherosclerosis, and inflammation. Further methods development in microscopy, small animal imaging, and flow cytometry/cell sorting core facilities will drive progress in the projects. We will also support selected pilot projects in promising new areas of vascular biology. Mentoring will emphasize the use of multiple disciplines to creatively address research problems. The strategy encourages collaborative research that enables investigators to compete successfully for dual or multi-investigator research grants. This will catalyze further expansion of a self-sustaining research center in vascular biology of the highest caliber.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Study Section
Special Emphasis Panel (ZRR1-CR-B (01))
Program Officer
Canto, Maria Teresa
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Oklahoma Medical Research Foundation
Oklahoma City
United States
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Dong, Yunzhou; Fernandes, Conrad; Liu, Yanjun et al. (2017) Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis. Diab Vasc Dis Res 14:14-23
Bergstrom, K; Fu, J; Johansson, M E V et al. (2017) Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol 10:91-103
Barboza, Erika; Hudson, Joanna; Chang, Wan-Pin et al. (2017) Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol 69:1221-1232
Bergstrom, Kirk; Liu, Xiaowei; Zhao, Yiming et al. (2016) Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology 151:152-164.e11
Rahman, H N Ashiqur; Wu, Hao; Dong, Yunzhou et al. (2016) Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res 118:957-969
Fu, Yao; Kinter, Michael; Hudson, Joanna et al. (2016) Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol 68:1887-98
Griffin, Timothy M; Humphries, Kenneth M; Kinter, Michael et al. (2016) Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie 124:74-83
Fu, Yao; Huebner, Janet L; Kraus, Virginia B et al. (2016) Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. J Gerontol A Biol Sci Med Sci 71:1131-40
Herlea-Pana, Oana; Yao, Longbiao; Heuser-Baker, Janet et al. (2015) Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression. Cardiovasc Res 106:324-37
Dong, Yunzhou; Wu, Hao; Rahman, H N Ashiqur et al. (2015) Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest 125:4349-64

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