The Pacific Northwest Dementia and Aging (PANDA) Neuropathology (NP) Group is a cooperative effort between the Alzheimer's Disease (AD) Center (ADC) at Oregon Health &Science University (OHSU) and the AD Research Center (ADRC) at the University of Washington (UW) that was initiated in July 2003. The initial four Specific Aims of the PANDA NP Group are unchanged from our previous applications: 1. Provide diagnostic expertise to the diverse population of the Pacific Northwest by providing family members of the deceased and physicians involved in their care with timely autopsy reports based on the most current standardized diagnostic criteria. 2. Facilitate research by collecting, storing and distributing a highly accessible, but appropriately safeguarded, repository of well-prepared brain tissue and neuropathologic data from carefully and longitudinally characterized patients with mild cognitive impairment (MCI) or dementia as well as noncognitively impaired control individuals using a variety of methods that maximizes utility to scientists. 3. Teach trainees in pathology, neurology, psychology, psychiatry, and basic sciences the current methods of neuropathological classification of neurodegenerative diseases and age-related changes, and mentor junior faculty in NP. 4. Develop innovative new approaches to maximize achievements in Aims 1 to 3. Two new Specific Aims are focused on Targeted Molecular Testing: 5. Quantify targeted cerebrospinal fluid (CSF) biomarkers in the UW ADRC CSF Bank that derives in large part from the OHSU ADC and UW ADRC Clinical Cores to enhance the value of these specimens for research while insuring proper safeguards. 6. Provide expert preparation of DNA and targeted genetic testing relevant to AD and related neurodegenerative diseases.

Public Health Relevance

The PANDA NP Group harmonizes the diagnostic, brain banking, teaching, and innovative functions of OHSU and the UW in a single functional entity spread between these two Centers. We have found this approach to be highly productive in the past and propose to continue to use this structure to increase our understanding of AD, incipient dementia, and healthy aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008017-25
Application #
8662584
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
25
Fiscal Year
2014
Total Cost
$207,065
Indirect Cost
$76,605
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Boise, Linda; Hinton, Ladson; Rosen, Howard J et al. (2016) Willingness to Be a Brain Donor: A Survey of Research Volunteers From 4 Racial/Ethnic Groups. Alzheimer Dis Assoc Disord :
Silbert, Lisa C; Dodge, Hiroko H; Lahna, David et al. (2016) Less Daily Computer Use is Related to Smaller Hippocampal Volumes in Cognitively Intact Elderly. J Alzheimers Dis 52:713-7
Brodaty, Henry; Woolf, Claudia; Andersen, Stacy et al. (2016) ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol 16:52
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
Abner, Erin L; Nelson, Peter T; Kryscio, Richard J et al. (2016) Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimers Dement 12:882-9
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-50
Boise, Linda; Hinton, Ladson; Rosen, Howard J et al. (2016) Will My Soul Go to Heaven If They Take My Brain? Beliefs and Worries About Brain Donation Among Four Ethnic Groups. Gerontologist :
Mancini, Martina; Schlueter, Heather; El-Gohary, Mahmoud et al. (2016) Continuous Monitoring of Turning Mobility and Its Association to Falls and Cognitive Function: A Pilot Study. J Gerontol A Biol Sci Med Sci 71:1102-8
White, Matthew T; Shaw, Leslie M; Xie, Sharon X et al. (2016) Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease. J Alzheimers Dis 51:463-70

Showing the most recent 10 out of 364 publications