The overall mission of the HU CFAR is to promote, facilitate and expand innovative multidisciplinary research among its members and their colleagues to bring an end to the HIV epidemic. Absolutely essential to this mission is the HU CFAR Clinical Gore By providing catalytic research support to clinical programs at each of the major Harvard teaching hospitals, and access to predominantly underserved patient populations at the Lemuel Shattuck Hospital, the HU CFAR Clinical Core has provided CFAR members as well as their non-member colleagues in academia and industry access to samples and patient data from an expanding number of well-defined cohorts. Moreover, the Clinical Core has established a Community Outreach Program to affected communities that has greatly enhanced the ability to recruit patients into clinical cohorts and clinical trials. The impact of the Clinical Core extends well beyond Boston, by providing a linkage to multiple international sites of Harvard-based HIV/AIDS research, both in terms of access to clinical samples and through a series of innovative and wide-ranging educational programs designed to facilitate clinical research. The components of translational research supported by the HU CFAR Clinical Core are either not funded or are only inadequately funded by other support mechanisms, and thus the value added of this Core has been immense. To address ongoing needs of HU CFAR investigators, we now propose to accomplish the following specific aims: 1. To provide infrastructure support for Harvard University (HU) CFAR investigators conducting clinical and basic science research related to HIV infection and its associated opportunistic infections. 2. To develop and provide access to databases and clinical specimen repositories from well-characterized HIV-infected populations. 3. To support educational and outreach programs designed to facilitate clinical and translational research at HU and at international sites associated with HU CFAR investigators.
The HU CFAR Clinical Core has played an active role and added value in the support of investigator-initiated projects by HU CFAR investigators and in fostering collaborative projects. In addition, the Core has provided training relevant to HIV-related projects and research, thereby adding value to a variety of educational initiatives.
|Ramirez-Avila, Lynn; Regan, Susan; Chetty, Senica et al. (2015) HIV testing rates, prevalence, and knowledge among outpatients in Durban, South Africa: Time trends over four years. Int J STD AIDS 26:704-9|
|Psaros, Christina; Barinas, Jennifer; Robbins, Gregory K et al. (2015) Reflections on living with HIV over time: exploring the perspective of HIV-infected women over 50. Aging Ment Health 19:121-8|
|Drain, Paul K; Losina, Elena; Coleman, Sharon M et al. (2015) Value of urine lipoarabinomannan grade and second test for optimizing clinic-based screening for HIV-associated pulmonary tuberculosis. J Acquir Immune Defic Syndr 68:274-80|
|Chan, Brian T; Weiser, Sheri D; Boum, Yap et al. (2015) Persistent HIV-related stigma in rural Uganda during a period of increasing HIV incidence despite treatment expansion. AIDS 29:83-90|
|Blashill, Aaron J; Goshe, Brett M; Robbins, Gregory K et al. (2014) Body image disturbance and health behaviors among sexual minority men living with HIV. Health Psychol 33:677-80|
|Rothchild, Alissa C; Jayaraman, Pushpa; Nunes-Alves, Cláudio et al. (2014) iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog 10:e1003805|
|Powis, Kathleen; Lockman, Shahin; Smeaton, Laura et al. (2014) Vitamin D insufficiency in HIV-infected pregnant women receiving antiretroviral therapy is not associated with morbidity, mortality or growth impairment in their uninfected infants in Botswana. Pediatr Infect Dis J 33:1141-7|
|Li, Hualin; Stephenson, Kathryn E; Kang, Zi Han et al. (2014) Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys. J Virol 88:13510-5|
|Sixsmith, Jaimie D; Panas, Michael W; Lee, Sunhee et al. (2014) Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques. Clin Vaccine Immunol 21:1385-95|
|Weinstein, Edward A; Ordonez, Alvaro A; DeMarco, Vincent P et al. (2014) Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography. Sci Transl Med 6:259ra146|
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