The expanded Core moved in 2008 from Harborview Medical Center to the SLU campus. Services include: Energy Balance: Advantages of our new Sable System include that it can be used for either mice or rats, generates 4x more data per unit time, and reduces animal stress by employing cages that contain bedding (unlike other calorimeter systems) and thus more closely resemble the animal's home cage. This equipment has also overcome previous obstacles related to food intake measurement and has several additional advantages over other systems (e.g., pair-feeding capability, measurement of food preferences and the ability to conduct metabolic studies in a wide range of temperature environments). Metabolic Imaging Subcore: The overall goal is to assist NORC Als in harnessing advanced technologies that allow for in vivo assessment of metabolic phenotypes and endpoints in both animal and human models by capitalizing on existing state-of-the-art facilities, equipment, and expertise. Although some of these imaging services can be obtained directly via the UW Department of Radiology, our Subcore markedly increases accessibility to while reducing costs to NORC Als for these services. Moreover, many imaging protocols described below were developed and validated by Subcore faculty specifically to meet the needs of NORC Als, and would not otherwise be available. Services components include consultative services for optimization of existing or new protocols, training, and ongoing technological support, effectively facilitating access for NORC Als to contact experts and supporting their ability to acquire and/or analyze imaging data on a fee-for-service basis. These goals are met by taking advantage of the substantial investment in sophisticated equipment and maintenance that exists within UW imaging facilities, under the direction of the UW Department of Radiology. Routine access to these services is limited by the need to independently generate and provide complete image acquisition protocols (which requires significant technological expertise, especially for MRI) and by the fact that once images are acquired, users are also responsible for image processing to measure their qualitative or quantitative radiologic outcomes. Moreover, existing facilities do not provide for animal handling, human subject safety screening, or administration of stimuli during fMRI. Lastly, we are pleased to offer funds to enable new imaging projects to be piloted at no charge to the investigator. By providing these services as well as consultation to Als, the Metabolic Imaging Subcore facilitates access to and use of available advanced imaging technologies.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Melhorn, Susan J; Tyagi, Vidhi; Smeraglio, Anne et al. (2014) Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite 82:85-90
Lemaitre, Rozenn N; King, Irena B; Rice, Kenneth et al. (2014) Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. Prostaglandins Leukot Essent Fatty Acids 91:149-53
Kaiyala, Karl J (2014) Mathematical model for the contribution of individual organs to non-zero y-intercepts in single and multi-compartment linear models of whole-body energy expenditure. PLoS One 9:e103301
Marina, Anna; von Frankenberg, Anize Delfino; Suvag, Seda et al. (2014) Effects of dietary fat and saturated fat content on liver fat and markers of oxidative stress in overweight/obese men and women under weight-stable conditions. Nutrients 6:4678-90
Spiezio, Sabrina H; Amon, Lynn M; McMillen, Timothy S et al. (2014) Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mamm Genome 25:549-63
Morton, Gregory J; Kaiyala, Karl J; Foster-Schubert, Karen E et al. (2014) Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans. J Clin Endocrinol Metab 99:E241-5
Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C et al. (2014) Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62:17-25
Williams, Paul T; Zhao, Xue-Qiao; Marcovina, Santica M et al. (2014) Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease. Atherosclerosis 233:713-20
Lee, Jung-Ting; Pamir, Nathalie; Liu, Ning-Chun et al. (2014) Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology 155:3409-20
Berkseth, Kathryn E; Guyenet, Stephan J; Melhorn, Susan J et al. (2014) Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology 155:2858-67

Showing the most recent 10 out of 404 publications