The overall goals of the Core have been to encourage NORC-H Investigators and Associate Investigators in utilizing molecular and genomic technologies, to train NORC-H Investigators in these techniques, and to provide selected centralized services to facilitate molecular and genomic studies. These goals have been met by providing one-on-one consultative services in long-term strategic planning of genomic-related studies, conducting tutorials and workshops on genomic and bioinformatics technologies, helping NORC-H Investigators and Associate Investigators trouble-shoot genomic procedures when they encounter a technical impasse, providing access to and training on specialized equipment, and providing high quality reagents for molecular and genomic studies. 1. Provide consultative services in bioinformatic analysis, including interpretation of global transcriptional profiling data obtained using Affymetrix GeneChips or RNAseq technology. 2. Provide a variety of genomics-related services including deep sequencing, RNAseq, "nanoString"- based transcriptional profiling, and assistance in the development of high-content high-throughput assays using automated microscopic imaging. 3. Provide space and technical personnel for specialized genomics-related equipment. 4. Conduct tutorials and workshops in genomic and bioinformatic techniques. The equipment and specific services available in the NORC-H Genomics Core

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DK040561-18
Application #
8715763
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Carmody, Jill S; Muñoz, Rodrigo; Yin, Huali et al. (2016) Peripheral, but not central, GLP-1 receptor signaling is required for improvement in glucose tolerance after Roux-en-Y gastric bypass in mice. Am J Physiol Endocrinol Metab 310:E855-61
Sztam, Kevin A; Liu, Enju; Manji, Karim P et al. (2016) Maternal Antiretroviral Therapy Is Associated with Lower Risk of Diarrhea in Early Childhood. J Pediatr 175:54-60
Nou, Eric; Lo, Janet; Grinspoon, Steven K (2016) Inflammation, immune activation, and cardiovascular disease in HIV. AIDS 30:1495-509
Dichtel, Laura E; Eajazi, Alireza; Miller, Karen K et al. (2016) Short- and Long-Term Reproducibility of Intrahepatic Lipid Quantification by 1H-MR Spectroscopy and CT in Obesity. J Comput Assist Tomogr 40:678-82
Fullerton, Brenna S; Sparks, Eric A; Hall, Amber M et al. (2016) Enteral autonomy, cirrhosis, and long term transplant-free survival in pediatric intestinal failure patients. J Pediatr Surg 51:96-100
Heymsfield, S B; Peterson, C M; Thomas, D M et al. (2016) Why are there race/ethnic differences in adult body mass index-adiposity relationships? A quantitative critical review. Obes Rev 17:262-75
Sparks, Eric A; Khan, Faraz A; Fisher, Jeremy G et al. (2016) Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome. J Pediatr Surg 51:92-5
Fazeli, Pouneh K; Teoh, Jonathan G; Lam, Eleanor L et al. (2016) Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly. Growth Horm IGF Res 26:17-23
Peterson, Courtney M; Thomas, Diana M; Blackburn, George L et al. (2016) Universal equation for estimating ideal body weight and body weight at any BMI. Am J Clin Nutr 103:1197-203
Schulz, Tim J; Graja, Antonia; Huang, Tian Lian et al. (2016) Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia 59:1769-77

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