I. Evolution of the NORC Research Base. The strength of the UNC NORC research base is that it is both large enough and strong enough to effectively span a variety of disciplines within nutritional sciences and obesity related research. From population-based to molecular research, our Center gains from the integration of these diverse perspectives and approaches. Our faculty members are international leaders in nutrition and obesity research, publishing in top journals and directing major nutrition/obesity studies. At the population level, our investigators lead some of the largest NIH-funded nutrition-focused studies including the Long Island Breast Cancer Study (18,000 women), Atherosclerosis Risk in Communities (ARIC: 15,792 men and women), Trial of Activity in Adolescent Girls (TAAG: 8,728 women), WAY to Health Study (1,200 employees at 12 community colleges), The Hispanic Cohort Health Study (16,000 men and women) and the Carolina Head and Neck Cancer Study (CHANCE: 1,400 men and women), to name a few. Our investigators are at the leading edge of studying the global nutrition transition, with major longitudinal studies in the United States, China and the Philippines. At the clinical nutrition research level, we are leaders in the developing field of nutrigenomics as it influences dietary nutrient requirements (including organizing workshops for the American Society of Nutrition at the 2010 and 2011 Experimental Biology annual meetings). Our members have generated critical information needed for the Dietary Reference Intakes (DRI) development process, and several of our members served on the Institute of Medicine panels that developed those DRIs. At the molecular level, our investigators have made fundamental contributions to the understanding of the genes that regulate activity, lipid and choline metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and selenium modulate viral mutation and pathogenesis. We are also leaders in identifying, in both mice and humans, gene loci that regulate adipose distribution, insulin resistance, and glucose metabolism. These examples are only a small portion of the large number of contributions made by the NORC research base. The NORC leadership has worked hard to build a strong and diverse research base. We measure our success as a Center by the strength of our membership, the investment in nutrition and obesity research, and the quantity and quality of publications generated by our members.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Evans, Mary
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University of North Carolina Chapel Hill
Schools of Public Health
Chapel Hill
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Xue, Jing; Schoenrock, Sarah A; Valdar, William et al. (2016) Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations. Clin Epigenetics 8:107
Qin, Bo; Viera, Anthony J; Muntner, Paul et al. (2016) Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline. Hypertension 68:106-13
Qin, Yuanyuan; Sundaram, Sneha; Essaid, Luma et al. (2016) Weight loss reduces basal-like breast cancer through kinome reprogramming. Cancer Cell Int 16:26
Fry, Constance L; Naugle Jr, Thomas C; Cole, Shelley A et al. (2016) The Latino Eyelid: Anthropometric Analysis of a Spectrum of Findings. Ophthal Plast Reconstr Surg :
Zwart, Sara R; Gregory, Jesse F; Zeisel, Steven H et al. (2016) Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB J 30:141-8
Batis, Carolina; Mendez, Michelle A; Gordon-Larsen, Penny et al. (2016) Using both principal component analysis and reduced rank regression to study dietary patterns and diabetes in Chinese adults. Public Health Nutr 19:195-203
Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2016) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol :
Huang, Chi; Liu, Chao-Jie; Pan, Xiong-Fei et al. (2016) Correlates of unequal access to preventive care in China: a multilevel analysis of national data from the 2011 China Health and Nutrition Survey. BMC Health Serv Res 16:177
Zhang, Ji; Xue, Hong; Cheng, Xi et al. (2016) Influence of proximities to food establishments on body mass index among children in China. Asia Pac J Clin Nutr 25:134-41
Nilsson, Torbjörn K; Hurtig-Wennlöf, Anita; Sjöström, Michael et al. (2016) Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents. FASEB J 30:1683-8

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