This core serves to develop and make accessible technology for stochastic optical reconstruction microscopy (STORM), a combination of selective chromophore activation and computational reconstruction that has resolution in the 20-30 nm range. We begin with an instrument that was almost fully constructed, donated to the Core by the Corey Lab, but we needed to complete construction and develop a use-friendly interface appropriate for general use by a core user base. An additional goal was to continue to develop the instrument to reflect technological advances in STORM in the field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS072030-04
Application #
8733770
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Harvard Medical School
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Chow, Brian Wai; Gu, Chenghua (2017) Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation. Neuron 93:1325-1333.e3
Chen, Yao; Granger, Adam J; Tran, Trinh et al. (2017) Endogenous G?q-Coupled Neuromodulator Receptors Activate Protein Kinase A. Neuron 96:1070-1083.e5
Abraira, Victoria E; Kuehn, Emily D; Chirila, Anda M et al. (2017) The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168:295-310.e19
Cho, Jin-Hyung; Rendall, Sam D; Gray, Jesse M (2017) Brain-wide maps of Fos expression during fear learning and recall. Learn Mem 24:169-181
Zoeller, Jason J; Bronson, Roderick T; Selfors, Laura M et al. (2017) Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer 3:18
Lutas, Andrew; Lahmann, Carolina; Soumillon, Magali et al. (2016) The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife 5:
Straub, Christoph; Saulnier, Jessica Lizette; B├Ęgue, Aurelien et al. (2016) Principles of Synaptic Organization of GABAergic Interneurons in the Striatum. Neuron 92:84-92
Jackman, Skyler L; Turecek, Josef; Belinsky, Justine E et al. (2016) The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature 529:88-91
Dauth, Stephanie; Grevesse, Thomas; Pantazopoulos, Harry et al. (2016) Extracellular matrix protein expression is brain region dependent. J Comp Neurol 524:1309-36
Park, Sung-Jin; Gazzola, Mattia; Park, Kyung Soo et al. (2016) Phototactic guidance of a tissue-engineered soft-robotic ray. Science 353:158-62

Showing the most recent 10 out of 44 publications