This core serves to develop and make accessible technology for stochastic optical reconstruction microscopy (STORM), a combination of selective chromophore activation and computational reconstruction that has resolution in the 20-30 nm range. We begin with an instrument that was almost fully constructed, donated to the Core by the Corey Lab, but we needed to complete construction and develop a use-friendly interface appropriate for general use by a core user base. An additional goal was to continue to develop the instrument to reflect technological advances in STORM in the field.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30NS072030-04
Application #
8733770
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Harvard Medical School
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Wang, Shan Shan H; Held, Richard G; Wong, Man Yan et al. (2016) Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Neuron 91:777-91
Tang, Jonathan Cy; Drokhlyansky, Eugene; Etemad, Behzad et al. (2016) Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. Elife 5:
Jackman, Skyler L; Turecek, Josef; Belinsky, Justine E et al. (2016) The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature 529:88-91
Granger, Adam J; Mulder, Nicole; Saunders, Arpiar et al. (2016) Cotransmission of acetylcholine and GABA. Neuropharmacology 100:40-6
Hu, Yu; Kim, Ji Hyung; He, Kangmin et al. (2016) Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med 213:2759-2772
Mierau, Susanna B; Patrizi, Annarita; Hensch, Takao K et al. (2016) Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits. Biol Psychiatry 79:746-54
Held, Richard G; Liu, Changliang; Kaeser, Pascal S (2016) ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. Elife 5:
Witter, Laurens; Rudolph, Stephanie; Pressler, R Todd et al. (2016) Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons. Neuron 91:312-9
Saunders, Arpiar; Huang, Kee Wui; Sabatini, Bernardo Luis (2016) Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons. PLoS One 11:e0149798
Wang, Chih-Chieh; Weyrer, Christopher; Paturu, Mounica et al. (2016) Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse. J Neurosci 36:6393-402

Showing the most recent 10 out of 37 publications