The Animal Behavior Core will provide services, technical assistance and training needed for behavioral testing of mice and rats to satisfy the experimental aims of the investigators within the Research Components of the ACTG. A primary goal of the Animal Behavior Core is to standardize the methods and the analyses for alcohol-related behavioral testing for mice and rats. Core personnel will conduct all homecage drinking studies in mice and rats, and other ethanol-related behavioral tests, as required by the Research Components. The core will instruct research personnel in other behavioral procedures as needed. In addition, the Core will directly compare the rat operant self-administration procedures currently in use by Center Investigators. By conducting a considerable proportion of the behavioral testing within the Core, we ensure that the procedures are performed, and the data are analyzed, in a consistent manner, allowing for maximal comparability of the effects of different experimental manipulations across center projects. This model of centralized behavioral testing by the Animal Behavior Core worked extraordinarily well in the first funding period, allowing for smooth, efficient completion of many behavioral studies. The overall goal of the Animal Behavior Core is to assist Research Components in experiments that test hypotheses regarding the role of novel signaling molecules in alcohol drinking.
The search for new drug targets to develop treatments for alcohol use disorders requires careful testing within preclinical animal models. The Animal Behavior Core will collaborate with Research Components in experiments designed to manipulate excessive ethanol intake and relapse. These studies will seek to increase our understanding of alcohol addiction and open new possibilities for treatment.
|King, Ian F G; Eddison, Mark; Kaun, Karla R et al. (2014) EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior. PLoS One 9:e87714|
|Trudell, James R; Messing, Robert O; Mayfield, Jody et al. (2014) Alcohol dependence: molecular and behavioral evidence. Trends Pharmacol Sci 35:317-23|
|Darcq, Emmanuel; Hamida, Sami Ben; Wu, Su et al. (2014) Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. J Neurochem 129:1024-34|
|Lee, Anna M; Zou, Mimi E; Lim, Jana P et al. (2014) Deletion of Prkcz increases intermittent ethanol consumption in mice. Alcohol Clin Exp Res 38:170-8|
|Becker, Howard C; Ron, Dorit (2014) Animal models of excessive alcohol consumption: recent advances and future challenges. Alcohol 48:205-8|
|Neasta, Jeremie; Barak, Segev; Hamida, Sami Ben et al. (2014) mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem 130:172-84|
|Steinberg, Elizabeth E; Boivin, Josiah R; Saunders, Benjamin T et al. (2014) Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PLoS One 9:e94771|
|Carnicella, Sebastien; Ron, Dorit; Barak, Segev (2014) Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol 48:243-52|
|Ben Hamida, Sami; Darcq, Emmanuel; Wang, Jun et al. (2013) Protein tyrosine phosphatase * in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. J Neurosci 33:14369-78|
|Barak, Segev; Liu, Feng; Ben Hamida, Sami et al. (2013) Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci 16:1111-7|
Showing the most recent 10 out of 31 publications