The over-arching goal of the UT Houston Substance Abuse Research-Medication Development Center is to develop safe, effective medications for cocaine dependence. The current Center proposal focuses on elucidating behavioral and neurochemical mechanisms of cocaine dependence and using these findings to guide clinical trials for promising medications. The Advanced Clinical Design and Statistical Analysis Core (ACDSAC) will serve as a critical mechanism for promoting this goal by providing statistical/methodological support for NIDA-funded clinical trials in drug dependence taking place at University of Texas Health Science Center at Houston-Medication Development Center as well as consultation to other NIDA-funded centers. The ACDSAC will accomplish this by: 1) providing support for the design and analysis of conventional clinical trials; 2) advancing utilization of flexible/adaptive study designs for the development of more efficient clinical trials; 3) advancing statistical methodologies for the analysis of clinical trials with a focus on Bayesian modeling and the use of structural equation modeling methodologies for evaluation of mediational hypotheses of drug action. 4) serving as a liaison to the statistical and design divisions of the Center for Clinical Research and Evidence-Based Medicine as well as the Center for Clinical Translational Science, both of the University of Texas Health Science Center at Houston; 5) providing training to post-doctoral staff, fellows and students in study design and advanced quantitative methods; The Advanced Clinical Design and Statistical Analysis Core will advance the overall goal of the UT Houston Medication Development Center by providing advanced novel statistical design and analysis support for medication development clinical trials.

Public Health Relevance

The dearth of acceptable and effective treatments for substance dependence coupled with the heterogeneous nature of the patient population and the accruing wealth of neurobiological evidence concerning this problem argue that innovative design and analyses should be implemented to maximize the likelihood of identifying successful treatments in the most efficient way possible.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA009262-20
Application #
8660669
Study Section
Special Emphasis Panel (ZDA1-EXL-T)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
20
Fiscal Year
2014
Total Cost
$223,695
Indirect Cost
$74,565
Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Vujanovic, Anka A; Smith, Lia J; Green, Charles E et al. (2017) Development of a novel, integrated cognitive-behavioral therapy for co-occurring posttraumatic stress and substance use disorders: A pilot randomized clinical trial. Contemp Clin Trials 65:123-129
Wardle, Margaret C; Vincent, Jessica N; Suchting, Robert et al. (2017) Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder. J Subst Abuse Treat 72:32-39
Ma, Liangsuo; Steinberg, Joel L; Wang, Qin et al. (2017) A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects. Drug Alcohol Depend 173:39-46
Schmitz, Joy M; Green, Charles E; Hasan, Khader M et al. (2017) PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial. Addiction 112:1861-1868
Azadeh, Shabnam; Hobbs, Brian P; Ma, Liangsuo et al. (2016) Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage 125:813-824
Sharma, Jyoti; Rathnayaka, Nuvan; Green, Charles et al. (2016) Bradycardia as a Marker of Chronic Cocaine Use: A Novel Cardiovascular Finding. Behav Med 42:1-8
Vujanovic, Anka A; Rathnayaka, Nuvan; Amador, Christina D et al. (2016) Distress Tolerance: Associations With Posttraumatic Stress Disorder Symptoms Among Trauma-Exposed, Cocaine-Dependent Adults. Behav Modif 40:120-43
Vujanovic, Anka A; Wardle, Margaret C; Liu, Shijing et al. (2016) Attentional bias in adults with cannabis use disorders. J Addict Dis 35:144-53
Dias, Nadeeka R; Lane, Scott D; Rathnayaka, Nuvan et al. (2015) Demographic and psychological factors associated with lifetime cocaine use: An exploratory factor analysis of baseline questionnaires. Addict Disord Their Treat 14:70-77
Alcorn 3rd, Joseph L; Rathnayaka, Nuvan; Swann, Alan C et al. (2015) Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder. Psychol Rec 65:691-703

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