Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA028825-09
Application #
3482124
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1980-06-01
Project End
1991-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Hooven, Louisa Ada; Baird, William M (2008) Proteomic analysis of MCF-7 cells treated with benzo[a]pyrene, dibenzo[a,l]pyrene, coal tar extract, and diesel exhaust extract. Toxicology 249:1-10
Courter, Lauren A; Musafia-Jeknic, Tamara; Fischer, Kay et al. (2007) Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Toxicol Sci 95:63-73
Mahadevan, Brinda; Luch, Andreas; Atkin, Jennifer et al. (2007) Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture. J Biochem Mol Toxicol 21:101-9
Miranda, C L; Chung, W G; Wang-Buhler, J-L et al. (2006) Comparative in vitro metabolism of benzo[a]pyrene by recombinant zebrafish CYP1A and liver microsomes from beta-naphthoflavone-treated rainbow trout. Aquat Toxicol 80:101-8
Baird, William M; Hooven, Louisa A; Mahadevan, Brinda (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 45:106-14
Reliene, Ramune; Hlavacova, Alexandra; Mahadevan, Brinda et al. (2005) Diesel exhaust particles cause increased levels of DNA deletions after transplacental exposure in mice. Mutat Res 570:245-52
Musafia-Jeknic, Tamara; Mahadevan, Brinda; Pereira, Clifford et al. (2005) Long-term effects of a standardized complex mixture of urban dust particulate on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture. Toxicol Sci 88:358-66
Mahadevan, Brinda; Luch, Andreas; Bravo, Claudia F et al. (2005) Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo. Cancer Lett 227:25-32
Hooven, Louisa A; Mahadevan, Brinda; Keshava, Channa et al. (2005) Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. Bioorg Med Chem Lett 15:1283-7
Mahadevan, Brinda; Marston, Charis P; Dashwood, Wan-Mohaiza et al. (2005) Effect of a standardized complex mixture derived from coal tar on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture. Chem Res Toxicol 18:224-31

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