The project seeks to understand the role of pyruvate kinase as regulator of cancer metabolism. Insight into glycolytic and TCA cycle flux from metabolic profiles of cancer cell lines will reveal new drug targets and generate new regimes for diagnosis and treatment of cancer patients.

Public Health Relevance

The impact of this study is extremely high;this work could entirely change the field of cancer metabolism. I will provide a platform to study the complex network of central carbon metabolism with the possibility to follow changes upon tumor progression or perturbation by interference with drugs or molecular biology tools. The work proposed brings mechanistic insights into a key regulator of the tumor metabolome and paves the way to diagnose and treat not only mammary gland but also numerous other carcinomas

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Transition Award (R00)
Project #
5R00CA154887-04
Application #
8548103
Study Section
Special Emphasis Panel (NSS)
Program Officer
Spalholz, Barbara A
Project Start
2012-07-30
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$234,059
Indirect Cost
$15,696
Name
University of California Merced
Department
None
Type
Schools of Earth Sciences/Natur
DUNS #
113645084
City
Merced
State
CA
Country
United States
Zip Code
95343