This career development proposal aims to provide the necessary protected research time and training for Dr. Demmer to transition from his postdoctoral research position to an independent tenure track faculty position. The proposal is comprised of two phases: 1) A mentored phase focused on strengthening the candidate's publication record and obtaining additional training in research areas outside of the candidate's current expertise; and 2) a comprehensive research project to be carried out upon procurement of a research track faculty position. The proposed training will be carried out in the Mailman School of Public Health at Columbia University Medical Center. Specifically, the mentored postdoctoral phase will provide opportunities for advanced training in the following four modules: Module 1) Advanced measurement methods with focus on methodological approaches to quantifying infection as an etiologic exposure for chronic disease; Module 2) Type 2 diabetes mellitus epidemiology and pathophysiology; Module 3) Genomics, with an emphasis in bioinformatics and gene expression studies; Module 4) Dissemination of scientific findings and grant writing. The independent phase research aims to test the hypothesis that periodontal infection is an etiologic factor in the development of type 2 diabetes mellitus (DM). Dr. Demmer proposes to study whether baseline exposure to known periodontal pathogens is associated with progression of DM risk factors over two years of longitudinal follow-up. Dr. Demmer and colleagues will assess the two year progression of fasting glucose, insulin resistance and beta-cell dysfunction and compare these progression rates between participants with high vs. low colonization levels of selected periodontal pathogens. This will be achieved using a longitudinal cohort design among n=300 participants in a population of tri-ethnic men and women aged 30 - 55 years at baseline enrollment. The proposed design will carefully control for potential confounders such as baseline levels of fasting glucose, insulin, lipids, obesity, diet, age, smoking, ethnicity and gender. The proposed research can advance the scientific knowledge regarding the well-known association between periodontal infection and type 2 diabetes mellitus through its provision of a powerful study design appropriate for addressing temporality (i.e., do periodontal infections precede the onset of diabetes pathology). In addition, data on the independent contribution of infections to the underlying pathology of diabetes can be addressed for the first time using a population based, chronic infection model. The independent phase research project will significantly enhance the applicant's qualifications to serve as principal investigator on a future R-01 application - an explicit aim of this funding mechanism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Transition Award (R00)
Project #
5R00DE018739-04
Application #
8120346
Study Section
Special Emphasis Panel (NSS)
Program Officer
Atkinson, Jane C
Project Start
2010-08-01
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
4
Fiscal Year
2011
Total Cost
$236,826
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Demmer, Ryan T; Breskin, Alexander; Rosenbaum, Michael et al. (2017) The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J Clin Periodontol 44:255-265
Suglia, Shakira F; Demmer, Ryan T; Wahi, Richa et al. (2016) Depressive Symptoms During Adolescence and Young Adulthood and the Development of Type 2 Diabetes Mellitus. Am J Epidemiol 183:269-76
Goh, Charlene E; Kopp, Jacob; Papapanou, Panos N et al. (2016) Association Between Serum Antibodies to Periodontal Bacteria and Rheumatoid Factor in the Third National Health and Nutrition Examination Survey. Arthritis Rheumatol 68:2384-93
Colombo, Paolo C; Doran, Amanda C; Onat, Duygu et al. (2015) Venous congestion, endothelial and neurohormonal activation in acute decompensated heart failure: cause or effect? Curr Heart Fail Rep 12:215-22
Kotsakis, Georgios A; Thai, Ashley; Ioannou, Andreas L et al. (2015) Association between low-dose aspirin and periodontal disease: results from the continuous national health and nutrition examination survey (NHANES) 2011-2012. J Clin Periodontol 42:333-41
Boillot, Adrien; Demmer, Ryan T; Mallat, Ziad et al. (2015) Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis 242:418-23
Demmer, Ryan T; Gelb, Sara; Suglia, Shakira F et al. (2015) Sex differences in the association between depression, anxiety, and type 2 diabetes mellitus. Psychosom Med 77:467-77
Demmer, R T; Jacobs Jr, D R; Singh, R et al. (2015) Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study. J Dent Res 94:201S-11S
Feuer, Alexis J; Demmer, Ryan T; Thai, Ashley et al. (2015) Use of selective serotonin reuptake inhibitors and bone mass in adolescents: An NHANES study. Bone 78:28-33
Colombo, Paolo C; Onat, Duygu; Harxhi, Ante et al. (2014) Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation. Eur Heart J 35:448-54

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